Response of matrix metalloproteinase-9 to olfactory nerve injury.

Response of matrix metalloproteinase-9 to olfactory nerve injury. Research Abstract Details 

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Response of matrix metalloproteinase-9 to olfactory nerve injury. Abstract Text:

Richard M Costanzo,Lisa A Perrino,Masayoshi Kobayashi,

Matrix metalloproteinases function in the remodeling of the extracellular matrix during growth and development as well as in injury and disease processes. We examined the role of matrix metalloproteinase-9 in a model of olfactory nerve injury in mice. We measured changes in matrix metalloproteinase-9 protein levels for up to 60 days following olfactory nerve transection. Matrix metalloproteinase-9 levels increased within hours after injury, peaked at day 1 and were elevated for approximately 2 weeks before returning to control levels over the 60-day time period. The increase in matrix metalloproteinase-9 was temporally associated with the degeneration of olfactory neurons that follows nerve transection and with increased gliosis. Our results demonstrate a temporal relationship between matrix metalloproteinase-9 elevation, degeneration of olfactory neurons and gliosis.

Response of matrix metalloproteinase-9 to olfactory nerve injury. Publishing Authors By Initials

RM Costanzo,LA Perrino,M Kobayashi,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Response of matrix metalloproteinase-9 to olfactory nerve injury. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neuroreport

VOLUME: 17

Page Numbers: 1787-91

Journal Abbreviation: Neuroreport

ISSN: 0959-4965

DAY: 27

MONTH: Nov

YEAR: 2006

Response of matrix metalloproteinase-9 to olfactory nerve injury. Information

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LANGUAGE: eng

NlmUniqueID: 9100935

Response of matrix metalloproteinase-9 to olfactory nerve injury. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: enzymology

Chemical & Substance for Abstract: Response of matrix metalloproteinase-9 to olfactory nerve injury. Information

Substance Name: Matrix Metalloproteinase 9

Registry Number: EC 3.4.24.35

Grant and Affiliation Information for Response of matrix metalloproteinase-9 to olfactory nerve injury.

AFFILIATION: Department of Physiology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298-0551, USA. rcostanz@vcu.edu

Country: England

AGENCY: United States NIDCD

GRANT: DC000165

ACRONYM: DC

MEDLINETA: Neuroreport

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