Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation.

Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation. Abstract Text:

S Li,G W Arbuthnott,M J Jutras,J A Goldberg,D Jaeger,S Li,G W Arbuthnott,M J Jutras,J A Goldberg,D Jaeger,

Deep brain stimulation (DBS) is an effective treatment of Parkinson's disease (PD) for many patients. The most effective stimulation consists of high-frequency biphasic stimulation pulses around 130 Hz delivered between two active sites of an implanted depth electrode to the subthalamic nucleus (STN-DBS). Multiple studies have shown that a key effect of STN-DBS that correlates well with clinical outcome is the reduction of synchronous and oscillatory activity in cortical and basal ganglia networks. We hypothesized that antidromic cortical activation may provide an underlying mechanism responsible for this effect, because stimulation is usually performed in proximity to cortical efferent pathways. We show with intracellular cortical recordings in rats that STN-DBS did in fact lead to antidromic spiking of deep layer cortical neurons. Furthermore, antidromic spikes triggered a dampened oscillation of local field potentials in cortex with a resonant frequency around 120 Hz. The amplitude of antidromic activation was significantly correlated with an observed suppression of slow wave and beta band activity during STN-DBS. These findings were seen in ketamine-xylazine or isoflurane anesthesia in both normal and 6-hydroxydopamine (6-OHDA)-lesioned rats. Thus antidromic resonant activation of cortical microcircuits may make an important contribution toward counteracting the overly synchronous and oscillatory activity characteristic of cortical activity in PD.

Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation. Publishing Authors By Initials

S Li,GW Arbuthnott,MJ Jutras,JA Goldberg,D Jaeger,S Li,GW Arbuthnott,MJ Jutras,JA Goldberg,D Jaeger,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of neurophysiology

VOLUME: 98

Page Numbers: 3525-37

Journal Abbreviation: J. Neurophysiol.

ISSN: 0022-3077

DAY: 10

MONTH: 10

YEAR: 2007

Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375404

Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation.

AFFILIATION: Emory Univ., Dept. of Biology, 1510 Clifton Rd. NE, Atlanta, GA 30322. djaeger@emory.edu).

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Neurophysiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation Related Publications

• Aneurysms of the posterior communicating artery; report of five cases with operation.
• Controlled spacing of cationic gold nanoparticles by nanocrown RNA.
• Duplex sonography of hemodialysis access.
• Estradiol Up-regulates AUF1p45 Binding to Stabilizing Regions within the 3'-Untranslated Region of Estrogen Receptor {alpha} mRNA.
• How to write and publish a successful scientific article.
• Intracranial aneurysms.
• Irritating effect of iodized vegetable oils on the brain and spinal cord.
• Mitochondrial introgression and incomplete lineage sorting through space and time: phylogenetics of crotaphytid lizards.
• New strepsirrhine primate from the late Eocene of Peninsular Thailand (Krabi Basin).
• Noninvasive central venous pressure measurement by controlled compression sonography at the forearm.
• Peroxiredoxin systems in mycobacteria.
• Psychosocial outcome in bipolar I patients with a personality disorder.
• Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation.
• Surgical treatment of skull and brain injuries.
• [Electron-optical studies on the involuntary musculature of the pregnant human uterus.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]