Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo.

Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo. Research Abstract Details 

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Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo. Abstract Text:

Hatice Hasturk,Alpdogan Kantarci,Emilie Goguet-Surmenian,Amanda Blackwood,Chris Andry,Charles N Serhan,Thomas E Van Dyke,Hatice Hasturk,Alpdogan Kantarci,Emilie Goguet-Surmenian,Amanda Blackwood,Chris Andry,Charles N Serhan,Thomas E Van Dyke,

Resolvin E1 (RvE1) is a potent proresolving mediator of inflammation derived from omega-3 eicosapentaenoic acid that acts locally to stop leukocyte recruitment and promote resolution. RvE1 displays potent counter-regulatory and tissue-protective actions in vitro and in vivo. Periodontal disease is a local inflammatory disease initiated by bacteria characterized by neutrophil-mediated tissue injury followed by development of a chronic immune lesion. In this study, we report the treatment of established periodontitis using RvE1 as a monotherapy in rabbits compared with structurally related lipids PGE(2) and leukotriene B(4). PGE(2) and leukotriene B(4) each enhanced development of periodontitis and worsened the severity of disease. Promotion of resolution of inflammation as a therapeutic target with RvE1 resulted in complete restoration of the local lesion, and reduction in the systemic inflammatory markers C-reactive protein and IL-1beta. This report is the first to show that resolution of inflammation by a naturally occurring endogenous lipid mediator results in complete regeneration of pathologically lost tissues, including bone.

Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo. Publishing Authors By Initials

H Hasturk,A Kantarci,E Goguet-Surmenian,A Blackwood,C Andry,CN Serhan,TE Van Dyke,H Hasturk,A Kantarci,E Goguet-Surmenian,A Blackwood,C Andry,CN Serhan,TE Van Dyke,

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Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 179

Page Numbers: 7021-9

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 15

MONTH: Nov

YEAR: 2007

Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo. Information

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LANGUAGE: eng

NlmUniqueID: 2985117

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Grant and Affiliation Information for Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo.

AFFILIATION: Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Boston University, Boston, MA 02118, USA.

Country: United States

AGENCY: United States NIDCR

GRANT: P50-DE016191

ACRONYM: DE

MEDLINETA: J Immunol

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