Resistin polymorphisms are associated with muscle, bone, and fat phenotypes in white men and women.

Resistin polymorphisms are associated with muscle, bone, and fat phenotypes in white men and women. Research Abstract Details 

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Resistin polymorphisms are associated with muscle, bone, and fat phenotypes in white men and women. Abstract Text:

Emidio E Pistilli,Heather Gordish-Dressman,Richard L Seip,Joseph M Devaney,Paul D Thompson,Thomas B Price,Theodore J Angelopoulos,Priscilla M Clarkson,Niall M Moyna,Linda S Pescatello,Paul S Visich,Robert F Zoeller,Eric P Hoffman,Paul M Gordon,Emidio E Pistilli,Heather Gordish-Dressman,Richard L Seip,Joseph M Devaney,Paul D Thompson,Thomas B Price,Theodore J Angelopoulos,Priscilla M Clarkson,Niall M Moyna,Linda S Pescatello,Paul S Visich,Robert F Zoeller,Eric P Hoffman,Paul M Gordon,

OBJECTIVE: The biological function of resistin (RST) is unknown, although it may have roles in obesity, diabetes, and insulin resistance. The objective of this study was to examine the effects of single nucleotide polymorphisms (SNPs) in the human RST gene on muscle, bone, and adipose tissue phenotypes and in response to resistance training (RT). RESEARCH METHODS AND PROCEDURES: Subjects were white and consisted of strength (n = 482) and size (n = 409) cohorts who had not performed RT in the previous year. Subjects completed 12 weeks of structured, unilateral upper arm RT aimed at increasing the size and strength of the non-dominant arm, using their dominant arm as an untrained control. Strength measurements were taken pre- and post-12-week RT and consisted of elbow flexor isometric strength and one-repetition maximum during a biceps curl using free weights. Whole muscle, subcutaneous fat, and cortical bone volumes were measured by magnetic resonance imaging. Six RST SNPs were identified. Analysis of covariance was used to test for effects of the SNPs on pre- and post-muscle strength and whole muscle, fat, and bone volumes independent of gender, age, and body weight. RESULTS: Five RST SNPs (-537 A>C, -420 C>G, 398 C>T, 540 G>A, 980 C>G) were associated with measured phenotypes among subjects when stratified by BMI (<25, >/ or = 25 kg/m(2)). Several gender-specific associations were observed between RST SNPs and phenotypes among individuals with a BMI > or = 25. Conversely, only two associations were observed among individuals with a BMI < 25. DISCUSSION: These data support previous identified associations of RST with adipose tissue and demonstrate additional associations with bone and skeletal muscle that warrant further investigation.

Resistin polymorphisms are associated with muscle, bone, and fat phenotypes in white men and women. Publishing Authors By Initials

EE Pistilli,H Gordish-Dressman,RL Seip,JM Devaney,PD Thompson,TB Price,TJ Angelopoulos,PM Clarkson,NM Moyna,LS Pescatello,PS Visich,RF Zoeller,EP Hoffman,PM Gordon,EE Pistilli,H Gordish-Dressman,RL Seip,JM Devaney,PD Thompson,TB Price,TJ Angelopoulos,PM Clarkson,NM Moyna,LS Pescatello,PS Visich,RF Zoeller,EP Hoffman,PM Gordon,

For similar hormones, hormone substitutes, and hormone antagonists: hormones: peptide hormones: adipokines: resistin research abstracts see: hormones, hormone substitutes, and hormone antagonists: hormones: peptide hormones: adipokines: resistin research

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Resistin polymorphisms are associated with muscle, bone, and fat phenotypes in white men and women. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Obesity (Silver Spring, Md.)

VOLUME: 15

Page Numbers: 392-402

Journal Abbreviation:

ISSN: 1930-7381

DAY: 3

MONTH: Feb

YEAR: 2007

Resistin polymorphisms are associated with muscle, bone, and fat phenotypes in white men and women. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101264860

Resistin polymorphisms are associated with muscle, bone, and fat phenotypes in white men and women. Keywords Mesh Terms:

KEYWORDS: Resistin

MESH TERMS: genetics

Chemical & Substance for Abstract: Resistin polymorphisms are associated with muscle, bone, and fat phenotypes in white men and women. Information

Substance Name: Resistin

Registry Number: 0

Grant and Affiliation Information for Resistin polymorphisms are associated with muscle, bone, and fat phenotypes in white men and women.

AFFILIATION: Division of Exercise Physiology, School of Medicine, West Virginia University, Morgantown, WV 26506-9227, USA.

Country: United States

AGENCY: United States NINDS

GRANT: R01 NS40606

ACRONYM: NS

MEDLINETA: Obesity (Silver Spring)

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