Resistance of the female, as opposed to the male, intestine to i/r-mediated injury is associated with increased resistance to gut-induced distant organ injury.

Resistance of the female, as opposed to the male, intestine to i/r-mediated injury is associated with increased resistance to gut-induced distant organ injury. Research Abstract Details 

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Resistance of the female, as opposed to the male, intestine to i/r-mediated injury is associated with increased resistance to gut-induced distant organ injury. Abstract Text:

Edwin A Deitch,Eleonora Feketeova,Qi Lu,Sergy Zaets,Tamara L Berezina,George W Machiedo,Carl J Hauser,David H Livingston,Da-Zhong Xu,Edwin A Deitch,Eleonora Feketeova,Qi Lu,Sergy Zaets,Tamara L Berezina,George W Machiedo,Carl J Hauser,David H Livingston,Da-Zhong Xu,

We tested the hypothesis that the female intestine is more resistant to gut I/R injury than the male intestine by comparing the effects of the isolated pure gut I/R superior mesenteric artery occlusion (SMAO) model on gut morphology and whether SMAO-induced distant organ injury (lung, bone marrow [BM], neutrophils, and red blood cells [RBCs]) would differ between male and proestrus female rats. At 6 or 24 h after SMAO or sham SMAO, gut injury, lung permeability, pulmonary neutrophil sequestration, RBC deformability, and BM RBC and white blood cell progenitor growth were measured, as was the ability of the plasma from these rats to activate naive rat neutrophils. At both 6 and 24 h after SMAO, the female rats had significantly less intestinal injury and reduced gut-induced lung injury, BM suppression, RBC dysfunction, and neutrophil activation than male rats subjected to SMAO. These results indicate that the resistance of proestrus female rats to gut injury and gut-induced distant organ injury is greater than that observed in male rats.

Resistance of the female, as opposed to the male, intestine to i/r-mediated injury is associated with increased resistance to gut-induced distant organ injury. Publishing Authors By Initials

EA Deitch,E Feketeova,Q Lu,S Zaets,TL Berezina,GW Machiedo,CJ Hauser,DH Livingston,DZ Xu,EA Deitch,E Feketeova,Q Lu,S Zaets,TL Berezina,GW Machiedo,CJ Hauser,DH Livingston,DZ Xu,

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Resistance of the female, as opposed to the male, intestine to i/r-mediated injury is associated with increased resistance to gut-induced distant organ injury. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Shock (Augusta, Ga.)

VOLUME: 29

Page Numbers: 78-83

Journal Abbreviation: Shock

ISSN: 1073-2322

DAY: 4

MONTH: Jan

YEAR: 2008

Resistance of the female, as opposed to the male, intestine to i/r-mediated injury is associated with increased resistance to gut-induced distant organ injury. Information

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LANGUAGE: eng

NlmUniqueID: 9421564

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AFFILIATION: Department of Surgery, New Jersey Medical School, UMDNJ, Newark and the VA New Jersey Healthcare System, East Orange, New Jersey.

Country: United States

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MEDLINETA: Shock

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