Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda.

Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda. Research Abstract Details 

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Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda. Abstract Text:

Samuel L Nsobya,Christian Dokomajilar,Moses Joloba,Grant Dorsey,Philip J Rosenthal,

Key parasite polymorphisms were assessed in subjects treated for malaria with artesunate-amodiaquine in Tororo, Uganda. For pfcrt, all of the isolates tested had the CVIET haplotype. For pfmdr1, 86Y and 1246Y were common at baseline and their prevalences were significantly higher in new isolates after therapy, indicating that treatment selected for mutations associated with a decreased response to amodiaquine.

Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda. Publishing Authors By Initials

SL Nsobya,C Dokomajilar,M Joloba,G Dorsey,PJ Rosenthal,

For similar geographic locations: africa: africa south of the sahara: africa, eastern: uganda research abstracts see: geographic locations: africa: africa south of the sahara: africa, eastern: uganda research

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Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Antimicrobial agents and chemotherapy

VOLUME: 51

Page Numbers: 3023-5

Journal Abbreviation: Antimicrob. Agents Chemother.

ISSN: 0066-4804

DAY: 11

MONTH: 06

YEAR: 2007

Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 315061

Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda. Keywords Mesh Terms:

KEYWORDS: Uganda

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda. Information

Substance Name: Amodiaquine

Registry Number: 86-42-0

Grant and Affiliation Information for Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda.

AFFILIATION: Department of Medicine, Makerere University, Kampala, Uganda.

Country: United States

AGENCY: United States FIC

GRANT: K01 TW00007

ACRONYM: TW

MEDLINETA: Antimicrob Agents Chemother

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