Resampling based on geographic patterns of hepatitis virus infection reveals a common gene signature for early intrahepatic recurrence of hepatocellular carcinoma.

Resampling based on geographic patterns of hepatitis virus infection reveals a common gene signature for early intrahepatic recurrence of hepatocellular carcinoma. Research Abstract Details 

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Resampling based on geographic patterns of hepatitis virus infection reveals a common gene signature for early intrahepatic recurrence of hepatocellular carcinoma. Abstract Text:

Shunji Uchimura,Norio Iizuka,Takao Tamesa,Takanobu Miyamoto,Yoshihiko Hamamoto,Masaaki Oka,

The majority of hepatocellular carcinomas (HCCs) correlated with infection by either hepatitis B or C virus (HBV or HCV) showing various geographic distributions, making it impossible to identify common gene signatures responsible for HCC recurrence. In this study we performed in silico resampling analysis of DNA microarray data that can reproduce virtually the geographic distribution pattern of HBV and HCV in 6 representative geographic regions. With the use of the Fisher ratio, genes associated with early intrahepatic recurrence of HCC within 1 year of surgery were identified in the 6 geographic virtual cohorts, each consisting of 1,000 virtual samples. The top 100 genes among each virtual cohort were compared. Many human leukocyte antigen (HLA) family genes were common among the 6 geographic virtual cohorts, suggesting that this gene family represents the pathway most responsible for early intrahepatic recurrence of HCC worldwide. This resampling approach is useful for identifying common pathways involved in various aspects of HCC.

Resampling based on geographic patterns of hepatitis virus infection reveals a common gene signature for early intrahepatic recurrence of hepatocellular carcinoma. Publishing Authors By Initials

S Uchimura,N Iizuka,T Tamesa,T Miyamoto,Y Hamamoto,M Oka,

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Resampling based on geographic patterns of hepatitis virus infection reveals a common gene signature for early intrahepatic recurrence of hepatocellular carcinoma. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Anticancer research

VOLUME: 27

Page Numbers: 3323-30

Journal Abbreviation: Anticancer Res.

ISSN: 0250-7005

DAY: 27

MONTH: 11

YEAR: 2007

Resampling based on geographic patterns of hepatitis virus infection reveals a common gene signature for early intrahepatic recurrence of hepatocellular carcinoma. Information

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LANGUAGE: eng

NlmUniqueID: 8102988

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AFFILIATION: Department of Computer Science and Systems Engineering, Faculty of Engineering, Yamaguchi University, Yamaguchi, Japan.

Country: Greece

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MEDLINETA: Anticancer Res

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