Requirement of IL-4 and liver NK1+ T cells for concanavalin A-induced hepatic injury in mice.

Requirement of IL-4 and liver NK1+ T cells for concanavalin A-induced hepatic injury in mice. Research Abstract Details 

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Requirement of IL-4 and liver NK1+ T cells for concanavalin A-induced hepatic injury in mice. Abstract Text:

Con A-induced hepatic injury of mice accompanied by elevated transaminase was inhibited after in vivo depletion of liver NK cells and NK1+ T cells with intermediate TCR by anti-NK1 Ab or anti-IL-2Rbeta Ab. However, depletion of liver NK cells alone by anti-asialo-GM1 Ab did not inhibit hepatic injury. Although depletion of NK1+ T cells inhibited Con A-induced IL-2R expression of CD4+ high TCR (TCRhigh) cells and IL-4 mRNA expression of hepatic mononuclear cells, exogenous IL-4 engendered Con A-induced hepatic injury and endowed the expression of IL-2R of CD4+ TCRhigh cells. It was also found that in vivo treatment with anti-IL-4 Ab before Con A administration inhibited Con A-induced hepatic injury. In addition, although Con A did not induce hepatic injury in MHC class I-deficient mice, exogenous IL-4 again engendered severe hepatic injury in these mice. Further, while serum TNF-alpha levels induced by Con A were greatly decreased in NK1+ T cell-depleted mice and class I-deficient mice, TNF-alpha levels were recovered by exogenous IL-4. These findings reveal that although CD4+ TCRhigh cells in the liver and their production of TNF-alpha are the direct effectors of Con A-induced hepatic injury, liver NK1+ T cells also play an important role in this hepatitis model. Con A hepatitis may serve as an experimental model for human autoimmune hepatitis.

Requirement of IL-4 and liver NK1+ T cells for concanavalin A-induced hepatic injury in mice. Publishing Authors By Initials

For similar peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research

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Requirement of IL-4 and liver NK1+ T cells for concanavalin A-induced hepatic injury in mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 159

Page Numbers: 1537-42

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 1

MONTH: Aug

YEAR: 1997

Requirement of IL-4 and liver NK1+ T cells for concanavalin A-induced hepatic injury in mice. Information

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LANGUAGE: eng

NlmUniqueID: 2985117

Requirement of IL-4 and liver NK1+ T cells for concanavalin A-induced hepatic injury in mice. Keywords Mesh Terms:

KEYWORDS: Tumor Necrosis Factor-alpha

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: Requirement of IL-4 and liver NK1+ T cells for concanavalin A-induced hepatic injury in mice. Information

Substance Name: Interleukin-4

Registry Number: 207137-56-2

Grant and Affiliation Information for Requirement of IL-4 and liver NK1+ T cells for concanavalin A-induced hepatic injury in mice.

AFFILIATION: Department of Immunology, Niigata University School of Medicine, Japan.

Country: UNITED STATES

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MEDLINETA: J Immunol

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