Reproducible measurements to quantify cutaneous involvement in scleroderma.

Reproducible measurements to quantify cutaneous involvement in scleroderma. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Reproducible measurements to quantify cutaneous involvement in scleroderma. Abstract Text:

BACKGROUND AND DESIGN: Because the current assessment of scleroderma through clinical skin scoring is subjective and imprecise, we devised fully quantitative measures of cutaneous involvement. First, we developed image analysis software for calculating the density of dermal collagen from 58 scleroderma and 327 control biopsy specimens. Second, using a durometer gauge, we obtained measurements of skin hardness over 12 body regions for 13 patients with scleroderma and 100 controls. We obtained serial durometer measurements at 2-cm intervals over the arms of four patients with scleroderma, correlating them with blinded assessments of skin score. Third, we produced two-dimensional laser Doppler maps of cutaneous blood flow over the dorsal aspect of the hands of 10 patients with scleroderma and 16 controls and, with software, we determined the mean red blood cell flux, density of arteriolar islands, and percentage of avascular area at each measured site. RESULTS: Average collagen density was significantly higher in patients with scleroderma (88.5% +/- 6.9%) compared with that in controls (75% +/- 9.3%) (P < .001). Durometer measurements were significantly greater for patients with scleroderma (P < .05) over the finger, hand, wrist, forearm, and ventral aspect of the arm. In individual patients, the measurements paralleled with skin score. In patients with scleroderma, mean red blood cell flux (483.2 +/- 421.2 mV) and arteriolar island density (1.4 +/- 0.5/cm2) were significantly greater than were the control averages (276.3 +/- 146.3 mV [P < .03] and 1.0 +/- 0.5/cm2 [P < .013], respectively). CONCLUSIONS: Dermal collagen density and durometer measurements of skin hardness accurately quantify skin sclerosis in scleroderma and permit the determination of sclerotic borders, respectively. Increased cutaneous red blood cell flux and greater use of microvascular reserve reflect defects in vascular regulation inherent to the disease. These reproducible measurements will allow us to more precisely monitor the progression of scleroderma, evaluate its response to experimental treatments, and investigate its pathogenetic origins.

Reproducible measurements to quantify cutaneous involvement in scleroderma. Publishing Authors By Initials

For similar skin and connective tissue diseases: skin diseases research abstracts see: skin and connective tissue diseases: skin diseases research

PUBMED ID PMID:

MEDLINE DATE:

Reproducible measurements to quantify cutaneous involvement in scleroderma. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Archives of dermatology

VOLUME: 131

Page Numbers: 1160-6

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Oct

YEAR: 1995

Reproducible measurements to quantify cutaneous involvement in scleroderma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372433

Reproducible measurements to quantify cutaneous involvement in scleroderma. Keywords Mesh Terms:

KEYWORDS: Skin Diseases

MESH TERMS: pathology

Chemical & Substance for Abstract: Reproducible measurements to quantify cutaneous involvement in scleroderma. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for Reproducible measurements to quantify cutaneous involvement in scleroderma.

AFFILIATION: Department of Dermatology, Yale University School of Medicine, New Haven, Conn, USA.

Country: UNITED STATES

AGENCY: United States NIAMS

GRANT: AR41942

ACRONYM: AR

MEDLINETA: Arch Dermatol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Reproducible measurements to quantify cutaneous involvement in scleroderma Related Publications

• "Cutaneous manifestations of internal malignant tumors" by Becker, Kahn and Rothman, June 1942. Commentary: Migratory necrolytic erythema.
• Assessment of thyroid function and urinary and breast milk iodine concentrations in healthy newborns and their mothers in Tehran.
• Association of first-trimester thyroid function test values with thyroperoxidase antibody status, smoking, and multivitamin use.
• Basal cell nevus syndrome with inflammatory disease of the bowel.
• Breast milk iodine and perchlorate concentrations in lactating Boston-area women.
• Clinical and molecular analysis of arylsulfatase E in patients with brachytelephalangic chondrodysplasia punctata.
• Clinical studies of exposure to perchlorate in the United States.
• Computers and morphology.
• Effects of iodine on thyroid function in man.
• Ethical conflicts in long-term care of the aged.
• Evidence that high calcium and vitamin D intake decrease the risk of breast cancer in premenopausal women: implications for breast cancer prevention and screening.
• Expression of cytokeratin 19 in the diagnosis of thyroid papillary carcinoma by quantitative polymerase chain reaction.
• Graduate training in dermatology. opinions of those in training 1968.
• Impaired venous hemodynamics in a minority of patients with chronic leg ulcers due to sickle cell anemia.
• Interval percutaneous cholecystostomy is effective for decompression of the common bile duct in high-risk elderly patients prior to endoscopic retrograde cholangiopancreatography.
• National Health and Nutrition Examination Survey III thyroid-stimulating hormone (TSH)-thyroperoxidase antibody relationships demonstrate that TSH upper reference limits may be skewed by occult thyroid dysfunction.
• Predilection of hemolytic anemia-associated leg ulcers for the medial malleolus.
• Prednisone treatment for vestibular neuritis.
• Reproducible measurements to quantify cutaneous involvement in scleroderma.
• The effect of type of delivery and povidone-iodine application at delivery on cord dried-blood-specimen thyrotropin level and the rate of hyperthyrotropinemia in mature and normal-birth-weight neonates residing in an iodine-replete area: report of tehran
• The school system as the vehicle of preventive psychiatry.
• The use of immunohistologic analysis in differentiating cutaneous T-cell lymphoma from psoriasis and dermatitis.
• The use of the thematic apperception test in psychotherapy.
• Thyroid function and lipid subparticle sizes in patients with short-term hypothyroidism and a population-based cohort.
• Transient congenital hypothyroidism in an iodine-replete area is not related to parental consanguinity, mode of delivery, goitrogens, iodine exposure, or thyrotropin receptor autoantibodies.
• Use of methotrexate to treat isolated Graves ophthalmopathy developing years after thyroidectomy and iodine 131 treatment of papillary thyroid cancer.
• [Treatment of acute Chagas-Mazza disease]