Reproducibility of fundus autofluorescence measurements obtained using a confocal scanning laser ophthalmoscope.

Reproducibility of fundus autofluorescence measurements obtained using a confocal scanning laser ophthalmoscope. Research Abstract Details 

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Reproducibility of fundus autofluorescence measurements obtained using a confocal scanning laser ophthalmoscope. Abstract Text:

AIM: To evaluate the reproducibility of the background fundus autofluorescence measurements obtained using a confocal scanning laser ophthalmoscope. METHODS: 10 normal volunteers and 10 patients with retinal disease were included in the study. One eye per subject was chosen randomly. Five images of the same eye of each individual were obtained, after pupillary dilatation, by two investigators using a confocal scanning laser ophthalmoscope. Background fundus autofluorescence was measured at 7 degrees temporal to the fovea in normal volunteers and between 7 and 15 degrees temporal to the fovea in patients. Within session reproducibility of the measurements obtained by each investigator and interobserver reproducibility were evaluated. RESULTS: For investigator 1 the median values of fundus autofluorescence obtained were 31.9 units for normal volunteers and 27.3 units for patients. The median largest differences in readings in normal volunteers was 5.7 units (range 1.4-13.5 units) and in patients 4.2 units (1.5-15.1 units). For investigator 2 the median values of fundus autofluorescence obtained were 28.9 units for normal volunteers and 27.4 units for patients. The median largest difference in readings in normal volunteers was 3.6 units (2.7-11.7 units), and in patients 4.1 units (1.5-9.3 units). The median interobserver difference in readings in normal volunteers was 3.3 units and for patients 6.6 units. The median greatest interobserver difference in measurements obtained for normal volunteers was 8.8 units (8.4-23.0 units) and for patients 11.1 units (7.1-40.8 units). CONCLUSION: Within session reproducibility of the measurements of background fundus autofluorescence was satisfactory. Although interobserver reproducibility was moderate, the variability of the measurements of fundus autofluorescence between observers appears to be small when compared with variation in fundus autofluorescence with age and disease.

Reproducibility of fundus autofluorescence measurements obtained using a confocal scanning laser ophthalmoscope. Publishing Authors By Initials

For similar eye diseases: retinal diseases research abstracts see: eye diseases: retinal diseases research

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Reproducibility of fundus autofluorescence measurements obtained using a confocal scanning laser ophthalmoscope. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The British journal of ophthalmology

VOLUME: 83

Page Numbers: 276-9

Journal Abbreviation: Br J Ophthalmol

ISSN: 0007-1161

DAY: 28

MONTH: Mar

YEAR: 1999

Reproducibility of fundus autofluorescence measurements obtained using a confocal scanning laser ophthalmoscope. Information

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LANGUAGE: eng

NlmUniqueID: 421041

Reproducibility of fundus autofluorescence measurements obtained using a confocal scanning laser ophthalmoscope. Keywords Mesh Terms:

KEYWORDS: Retinal Diseases

MESH TERMS: metabolism

Chemical & Substance for Abstract: Reproducibility of fundus autofluorescence measurements obtained using a confocal scanning laser ophthalmoscope. Information

Substance Name: Lipofuscin

Registry Number: 0

Grant and Affiliation Information for Reproducibility of fundus autofluorescence measurements obtained using a confocal scanning laser ophthalmoscope.

AFFILIATION: Institute of Ophthalmology, London.

Country: ENGLAND

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MEDLINETA: Br J Ophthalmol

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