Reproducibility of carotid intima-media thickness measurements in young adults.

Reproducibility of carotid intima-media thickness measurements in young adults. Research Abstract Details 

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Reproducibility of carotid intima-media thickness measurements in young adults. Abstract Text:

PURPOSE: To prospectively compare the reproducibility of carotid intima-media thickness (CIMT) measurements obtained from the right and left carotid arteries in young adults by using ultrasonographic (US) images acquired at the maximum dimension, minimum dimension, and electrocardiographically (ECG)-triggered cardiac end diastole. MATERIALS AND METHODS: This study was HIPAA compliant and approved by the institutional review board; all participants provided informed consent. Medical history, anthropometric measurements, and blood pressure (BP) values were obtained from 50 men and 50 women aged 18-25 years. Images of the common carotid arteries were acquired from three independent complete cardiac cycles by using a 15L8-MHz US transducer. CIMT was measured on the images of each cycle that depicted the narrowest and widest vessel diameters, and at the R wave of the ECG. Measurements from the right and left carotid arteries were analyzed by using paired t tests; possible sex differences, by using unpaired t tests. Reproducibility was determined by using coefficients of variation and intraclass correlations (ICCs). Pearson correlations and multiple regression analyses were used to compare CIMT, body mass index (BMI), and BP. RESULTS: CIMT values were 7.2% and 7% greater in frames showing the narrowest lumen diameter and in R-wave ECG-triggered frames, respectively, than in those with the widest diameter. CIMT measurements were 2.2%-3.1% greater in the right carotid artery than in the left (P < .001) and were significantly related to BMI (r = 0.40, P < .001) and systolic BP (r = 0.34, P < .001). ICCs were stronger when assessments were obtained in three different cardiac cycles (0.92-0.98), rather than in one (0.79-0.91). CONCLUSION: In healthy young adults, reproducibility of CIMT measurements is greatest when combining values from both carotid arteries and/or from the maximal and minimal arterial diameters.

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Reproducibility of carotid intima-media thickness measurements in young adults. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Radiology

VOLUME: 247

Page Numbers: 465-71

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ISSN: 1527-1315

DAY: 18

MONTH: 03

YEAR: 2008

Reproducibility of carotid intima-media thickness measurements in young adults. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Reproducibility of carotid intima-media thickness measurements in young adults.

AFFILIATION: Department of Radiology, Children's Hospital Los Angeles, MS No. 81, 4650 Sunset Blvd, Los Angeles, CA 90027, USA.

Country: United States

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MEDLINETA: Radiology

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