Reproducibility of BOLD, perfusion, and CMRO2 measurements with calibrated-BOLD fMRI.

Reproducibility of BOLD, perfusion, and CMRO2 measurements with calibrated-BOLD fMRI. Research Abstract Details 

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Reproducibility of BOLD, perfusion, and CMRO2 measurements with calibrated-BOLD fMRI. Abstract Text:

Oleg Leontiev,Richard B Buxton,

The coupling of changes in cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO(2)) during brain activation can be characterized by an empirical index, n, defined as the ratio between fractional CBF change and fractional CMRO(2) change. The combination of blood oxygenation level dependent (BOLD) imaging with CBF measurements from arterial spin labeling (ASL) provides a potentially powerful experimental approach for measuring n, but the reproducibility of the technique previously has not been assessed. In this study, inter-subject variance and intra-subject reproducibility of the method were determined. Block design %BOLD and %CBF responses to visual stimulation and mild hypercapnia (5% CO(2)) were measured, and these data were used to compute the BOLD scaling factor M, %CMRO(2) change with activation, and the coupling index n. Reproducibility was determined for three approaches to defining regions-of-interest (ROIs): 1) Visual area V1 determined from prior retinotopic maps, 2) BOLD-activated voxels from a separate functional localizer, and 3) CBF-activated voxels from a separate functional localizer. For estimates of %BOLD, %CMRO(2) and n, intra-subject reproducibility was found to be best for regions selected according to CBF activation. Among all fMRI measurements, estimates of n were the most robust and were substantially more stable within individual subjects (coefficient of variation, CV=7.4%) than across the subject pool (CV=36.9%). The stability of n across days, despite wider variability of CBF and CMRO(2) responses, suggests that the reproducibility of blood flow changes is limited by variation in the oxidative metabolic demand. We conclude that the calibrated BOLD approach provides a highly reproducible measurement of n that can serve as a useful quantitative probe of the coupling of blood flow and energy metabolism in the brain.

Reproducibility of BOLD, perfusion, and CMRO2 measurements with calibrated-BOLD fMRI. Publishing Authors By Initials

O Leontiev,RB Buxton,

For similar nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: occipital lobe: visual cortex research abstracts see: nervous system: central nervous system: brain: prosencephalon: telencephalon: cerebrum: cerebral cortex: occipital lobe: visual cortex research

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Reproducibility of BOLD, perfusion, and CMRO2 measurements with calibrated-BOLD fMRI. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: NeuroImage

VOLUME: 35

Page Numbers: 175-84

Journal Abbreviation: Neuroimage

ISSN: 1053-8119

DAY: 5

MONTH: 01

YEAR: 2007

Reproducibility of BOLD, perfusion, and CMRO2 measurements with calibrated-BOLD fMRI. Information

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LANGUAGE: eng

NlmUniqueID: 9215515

Reproducibility of BOLD, perfusion, and CMRO2 measurements with calibrated-BOLD fMRI. Keywords Mesh Terms:

KEYWORDS: Visual Cortex

MESH TERMS: physiology

Chemical & Substance for Abstract: Reproducibility of BOLD, perfusion, and CMRO2 measurements with calibrated-BOLD fMRI. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Reproducibility of BOLD, perfusion, and CMRO2 measurements with calibrated-BOLD fMRI.

AFFILIATION: Department of Radiology and Center for Functional MRI, University of California, San Diego, CA 92093-0677, USA.

Country: United States

AGENCY: United States NINDS

GRANT: R01 NS42069-04

ACRONYM: NS

MEDLINETA: Neuroimage

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