Repression of retinoic acid-induced transactivation by embryonal LTR binding protein.

Repression of retinoic acid-induced transactivation by embryonal LTR binding protein. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Repression of retinoic acid-induced transactivation by embryonal LTR binding protein. Abstract Text:

N Kotomura,M Okada,Y Ninomiya,T Tsukiyama,K Umesono,R M Evans,O Niwa,

The mechanism of repression of transcription by ELP, the embryonal long terminal repeat binding protein, was investigated. ELP represses the Moloney murine leukemia virus long terminal repeat by binding to a site which overlaps with a sequence element for retinoic acid receptor binding. This suggests possible competition of ELP with retinoic acid receptor for the same sequence elements. Oligonucleotides corresponding to ELP and/or retinoic acid receptor binding elements were placed upstream of the SV40 promoter and their effect on gene expression was analyzed by CAT assay. Elements which have affinity to both ELP and retinoic acid receptor were activated by retinoic acid receptor and these activations were repressed by ELP. An ELP binding element without affinity to retinoic acid receptor was insensitive to both activation by retinoic acid receptor and repression by ELP. Furthermore, cellular ELP binding elements and the Moloney leukemia virus long terminal repeat were activated by retinoic acid. These data suggest that one of the mechanism of transcriptional repression by ELP is competition for binding sites with transactivators such as retinoic acid receptors.

Repression of retinoic acid-induced transactivation by embryonal LTR binding protein. Publishing Authors By Initials

N Kotomura,M Okada,Y Ninomiya,T Tsukiyama,K Umesono,RM Evans,O Niwa,

For similar organic chemicals: hydrocarbons: hydrocarbons, acyclic: alkenes: polyenes: carotenoids: retinoids: vitamin a: tretinoin research abstracts see: organic chemicals: hydrocarbons: hydrocarbons, acyclic: alkenes: polyenes: carotenoids: retinoids: vitamin a: tretinoin research

PUBMED ID PMID:

MEDLINE DATE:

Repression of retinoic acid-induced transactivation by embryonal LTR binding protein. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 116

Page Numbers: 1309-16

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Dec

YEAR: 1994

Repression of retinoic acid-induced transactivation by embryonal LTR binding protein. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376600

Repression of retinoic acid-induced transactivation by embryonal LTR binding protein. Keywords Mesh Terms:

KEYWORDS: Tretinoin

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Repression of retinoic acid-induced transactivation by embryonal LTR binding protein. Information

Substance Name: Tretinoin

Registry Number: 302-79-4

Grant and Affiliation Information for Repression of retinoic acid-induced transactivation by embryonal LTR binding protein.

AFFILIATION: Department of Molecular Pathology, Hiroshima University.

Country: JAPAN

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Biochem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Repression of retinoic acid-induced transactivation by embryonal LTR binding protein Related Publications

• A clottable protein (coagulogen) from amoebocyte lysate of Japanese horseshoe crab (Tachypleus tridentatus). Its isolation and biochemical properties.
• A clotting enzyme associated with the hemolymph coagulation system of horseshoe crab (Tachypleus tridentatus): its purification and characterization.
• Ammonia IRMS-TPD measurements and DFT calculation on acidic hydroxyl groups in CHA-type zeolites.
• Cerebral Blood Flow before and after Treatment with Amlodipine in Elderly Patients with Lacunar Infarction.
• Completion of first meiosis by sperm penetration in vitro of bovine oocytes inhibited at metaphase-I with dimethylsulphoxide.
• Direct identification of disulfide bond linkages in human insulin-like growth factor I (IGF-I) by chemical synthesis.
• Effects of fetal calf serum in culture medium on development of bovine oocytes matured and fertilized in vitro.
• Electrochemical surface plasmon resonance measurement in a microliter volume flow cell for evaluating the affinity and catalytic activity of biomolecules.
• Further studies on the chromogenic substrate assay method for bacterial endotoxins using horseshoe crab (Tachypleus tridentatus) hemocyte lysate.
• Genomic organization and isoforms of the mouse ELP gene.
• Histamine sensitizing factor of Bordetella pertussis.
• Introduction: uremia research and toxicity.
• Isolation and biological activities of limulus anticoagulant (anti-LPS factor) which interacts with lipopolysaccharide (LPS).
• Open conformation chromatin and pluripotency.
• Oral Sorbent AST-120 Increases Renal NO Synthesis in Uremic Rats.
• Pericytes from brain microvessels strengthen the barrier integrity in primary cultures of rat brain endothelial cells.
• Phenolic Constituents of Wikstroemia retusa.
• Prolongation of P300 latency is associated with the duration of illness in male schizophrenia patients.
• Radiation induced dynamic mutations and transgenerational effects.
• Repression of retinoic acid-induced transactivation by embryonal LTR binding protein.
• Roles of organic anion transporters in the progression of chronic renal failure.
• Structure-activity relationship study on the 6-membered heteroaromatic ring system of diphenylpyrazine-type prostacyclin receptor agonists.
• The importance of NaCl concentration in a chemically defined medium for the development of bovine oocytes matured and fertilized in vitro.
• [A clinical case of serious disease of muscles involving loss of function caused by pseudoparalysis.]
• [Computer sciences and drug development]
• [Progress of infants contracting tuberculosis during their nursing period after infection.]
• [The first-stage diagnosis of children whose tuberculin reaction has been ascertained to have changed to the positive.]
• [The first-stage diagnosis of infants whose first chances of infection with tuberculosis could have been estimated although the positive reaction of tuberculin could not have been ascertained.]
• [The influence of measles, contracted by infants during their nursing period, on tuberculosis.]
• [The influence of pertussis on tuberculosis contracted by infants during their nursing period.]