Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres.

Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres. Research Abstract Details 

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Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres. Abstract Text:

Amra Grudic,Asne Jul-Larsen,Stuart J Haring,Marc S Wold,Per Eystein ,Rolf Bjerkvig,Stig Ove ,Amra Grudic,Asne Jul-Larsen,Stuart J Haring,Marc S Wold,Per Eystein ,Rolf Bjerkvig,Stig Ove ,

The activation of a telomere maintenance mechanism is required for cancer development in humans. While most tumors achieve this by expressing the enzyme telomerase, a fraction (5-15%) employs a recombination-based mechanism termed alternative lengthening of telomeres (ALT). Here we show that loss of the single-stranded DNA-binding protein replication protein A (RPA) in human ALT cells, but not in telomerase-positive cells, causes increased exposure of single-stranded G-rich telomeric DNA, cell cycle arrest in G2/M phase, accumulation of single-stranded telomeric DNA within ALT-associated PML bodies (APBs), and formation of telomeric aggregates at the ends of metaphase chromosomes. This study demonstrates differences between ALT cells and telomerase-positive cells in the requirement for RPA in telomere processing and implicates the ALT mechanism in tumor cells as a possible therapeutic target.

Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres. Publishing Authors By Initials

A Grudic,A Jul-Larsen,SJ Haring,MS Wold,PE ,R Bjerkvig,SO ,A Grudic,A Jul-Larsen,SJ Haring,MS Wold,PE ,R Bjerkvig,SO ,

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Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nucleic acids research

VOLUME: 35

Page Numbers: 7267-78

Journal Abbreviation: Nucleic Acids Res.

ISSN: 1362-4962

DAY: 24

MONTH: 10

YEAR: 2007

Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres. Information

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LANGUAGE: eng

NlmUniqueID: 411011

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Grant and Affiliation Information for Replication protein A prevents accumulation of single-stranded telomeric DNA in cells that use alternative lengthening of telomeres.

AFFILIATION: Section of Oncology, Department of Medicine, Haukeland University Hospital.

Country: England

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MEDLINETA: Nucleic Acids Res

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