Replication fork stalling at natural impediments.

Replication fork stalling at natural impediments. Research Abstract Details 

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Replication fork stalling at natural impediments. Abstract Text:

Ekaterina V Mirkin,Sergei M Mirkin,

Accurate and complete replication of the genome in every cell division is a prerequisite of genomic stability. Thus, both prokaryotic and eukaryotic replication forks are extremely precise and robust molecular machines that have evolved to be up to the task. However, it has recently become clear that the replication fork is more of a hurdler than a runner: it must overcome various obstacles present on its way. Such obstacles can be called natural impediments to DNA replication, as opposed to external and genetic factors. Natural impediments to DNA replication are particular DNA binding proteins, unusual secondary structures in DNA, and transcription complexes that occasionally (in eukaryotes) or constantly (in prokaryotes) operate on replicating templates. This review describes the mechanisms and consequences of replication stalling at various natural impediments, with an emphasis on the role of replication stalling in genomic instability.

Replication fork stalling at natural impediments. Publishing Authors By Initials

EV Mirkin,SM Mirkin,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

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Replication fork stalling at natural impediments. Journal Published:

PUBLICATION TYPE: Review

Journal: Microbiology and molecular biology reviews : MMBR

VOLUME: 71

Page Numbers: 13-35

Journal Abbreviation: Microbiol. Mol. Biol. Rev.

ISSN: 1092-2172

DAY: 3

MONTH: Mar

YEAR: 2007

Replication fork stalling at natural impediments. Information

Number of References: 311

LANGUAGE: eng

NlmUniqueID: 9706653

Replication fork stalling at natural impediments. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: genetics

Chemical & Substance for Abstract: Replication fork stalling at natural impediments. Information

Substance Name: Saccharomyces cerevisiae Proteins

Registry Number: 0

Grant and Affiliation Information for Replication fork stalling at natural impediments.

AFFILIATION: Department of Biology, Tufts University, Medford, MA 02155, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM 60987

ACRONYM: GM

MEDLINETA: Microbiol Mol Biol Rev

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