Replicase genes of murine coronavirus strains A59 and JHM are interchangeable: differences in pathogenesis map to the 3' one-third of the genome.

Replicase genes of murine coronavirus strains A59 and JHM are interchangeable: differences in pathogenesis map to the 3' one-third of the genome. Research Abstract Details 

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Replicase genes of murine coronavirus strains A59 and JHM are interchangeable: differences in pathogenesis map to the 3' one-third of the genome. Abstract Text:

Sonia Navas-Martin,Maarten Brom,Ming-Ming Chua,Richard Watson,Zhaozhu Qiu,Susan R Weiss,

The important roles of the spike protein and other structural proteins in murine coronavirus (MHV) pathogenesis have been demonstrated; however, the role of the replicase gene remains unexplored. We assessed the influence of the replicase genes of the highly neurovirulent MHV-JHM strain and the hepatotropic and mildly neurovirulent A59 strain in acute infection of the mouse. Analysis of chimeric A59/JHM recombinant viruses indicates that the replicase genes are interchangeable and that it is the 3' end of the genome, encoding the structural proteins, rather than the replicase gene, that determines the pathogenic properties of these chimeras.

Replicase genes of murine coronavirus strains A59 and JHM are interchangeable: differences in pathogenesis map to the 3' one-third of the genome. Publishing Authors By Initials

S Navas-Martin,M Brom,MM Chua,R Watson,Z Qiu,SR Weiss,

For similar genetic processes: recombination, genetic research abstracts see: genetic processes: recombination, genetic research

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Replicase genes of murine coronavirus strains A59 and JHM are interchangeable: differences in pathogenesis map to the 3' one-third of the genome. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of virology

VOLUME: 81

Page Numbers: 1022-6

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 1

MONTH: 11

YEAR: 2006

Replicase genes of murine coronavirus strains A59 and JHM are interchangeable: differences in pathogenesis map to the 3' one-third of the genome. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 113724

Replicase genes of murine coronavirus strains A59 and JHM are interchangeable: differences in pathogenesis map to the 3' one-third of the genome. Keywords Mesh Terms:

KEYWORDS: Recombination, Genetic

MESH TERMS: metabolism

Chemical & Substance for Abstract: Replicase genes of murine coronavirus strains A59 and JHM are interchangeable: differences in pathogenesis map to the 3' one-third of the genome. Information

Substance Name: RNA Replicase

Registry Number: EC 2.7.7.48

Grant and Affiliation Information for Replicase genes of murine coronavirus strains A59 and JHM are interchangeable: differences in pathogenesis map to the 3' one-third of the genome.

AFFILIATION: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. sonia.navas-martin@drexelmed.edu

Country: United States

AGENCY: United States NINDS

GRANT: NS54695

ACRONYM: NS

MEDLINETA: J Virol

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