Repeated administrations of concanavalin A induce Th1 to Th2 cytokine shift and tolerance against liver injury in mice.

Repeated administrations of concanavalin A induce Th1 to Th2 cytokine shift and tolerance against liver injury in mice. Research Abstract Details 

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Repeated administrations of concanavalin A induce Th1 to Th2 cytokine shift and tolerance against liver injury in mice. Abstract Text:

Yosui Tamaki,Masashi Yoneda,Keisuke Sato,Shiro Yokohama,Masakazu Haneda,Kimihide Nakamura,

The intravenous injection of concanavalin A (Con A) activates T cells and induces cytokine dependent liver injury in mice. However, the effect of repeated administrations of Con A has not been fully investigated. Female BALB/c mice were intravenously injected with Con A (20mg/kg) or saline once a week for six times. Mice were rechallenged with Con A 17 days after repeated administrations of Con A. Repeated Con A administrations elicited a sustained inhibition of rechallenged-Con A-induced liver injury. Plasma TNF-alpha and IFN-gamma levels after rechallenge of Con A were decreased compared with that of repeated saline treatments. By contrast, plasma IL-4 and IL-10 levels after rechallenge of Con A were increased. In spleen cells prepared from repeated Con A treated mice, the production of TNF-alpha and IFN-gamma 24h after co-incubation with Con A decreased, and that of IL-4 and IL-10 increased. In naive mice, plasma ALT level after Con A injection was decreased by the transfer of spleen cells prepared from the repeated Con A treated mice. The repeated administrations of Con A elicited Th1 to Th2 cytokine shift and the tolerant state against the Con A-induced liver injury in mice.

Repeated administrations of concanavalin A induce Th1 to Th2 cytokine shift and tolerance against liver injury in mice. Publishing Authors By Initials

Y Tamaki,M Yoneda,K Sato,S Yokohama,M Haneda,K Nakamura,

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Repeated administrations of concanavalin A induce Th1 to Th2 cytokine shift and tolerance against liver injury in mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hepatology research : the official journal of the

VOLUME: 35

Page Numbers: 242-9

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ISSN: 1386-6346

DAY: 3

MONTH: 07

YEAR: 2006

Repeated administrations of concanavalin A induce Th1 to Th2 cytokine shift and tolerance against liver injury in mice. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Repeated administrations of concanavalin A induce Th1 to Th2 cytokine shift and tolerance against liver injury in mice.

AFFILIATION: Second Department of Internal Medicine, Asahikawa Medical College, Asahikawa, Japan.

Country: Netherlands

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MEDLINETA: Hepatol Res

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