Repair of ulnar segmental defect by recombinant human bone morphogenetic protein-2 in dogs.

Repair of ulnar segmental defect by recombinant human bone morphogenetic protein-2 in dogs. Research Abstract Details 

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Repair of ulnar segmental defect by recombinant human bone morphogenetic protein-2 in dogs. Abstract Text:

T Itoh,M Mochizuki,R Nishimura,S Matsunaga,T Kadosawa,S Kokubo,S Yokota,N Sasaki,

The efficacy of recombinant human bone morphogenetic protein-2 (rhBMP-2) combined with poly D, L lactic-co-glycolic acid (PLGA)/gelatin sponge complex (PGS) as a carrier on the repair of segmental long-bone defects was evaluated using an ulnar model in dogs. The defect was 2 cm in length and was fixed with bone plating. After implantation of PGS with or without rhBMP-2, the repair process of the defect was evaluated by serial radiography until 16 postoperative weeks. All defects treated with 160 micrograms or 640 micrograms of rhBMP-2/PGS revealed bone union radiographically by 12 postoperative weeks, whereas all defects treated with PGS alone revealed no radiographic evidence of healing throughout the experimental period. In defects treated with 40 micrograms of rhBMP-2/PGS, new bone appeared partially at the defects but did not accomplish union. Bone mineral contents at the defect sites after harvest at 16 weeks postoperatively were significantly (p < 0.05) higher in those treated with 160 micrograms or 640 micrograms of rhBMP-2 than in those treated with 40 micrograms of rhBMP-2 or PGS alone. Histologically, defects radiographically diagnosed as having achieved union showed the appearance of cortical bone and bone marrow cells. These findings suggest the use of rhBMP-2/PGS as a potential bone graft substitute in reconstructive surgery in dogs.

Repair of ulnar segmental defect by recombinant human bone morphogenetic protein-2 in dogs. Publishing Authors By Initials

T Itoh,M Mochizuki,R Nishimura,S Matsunaga,T Kadosawa,S Kokubo,S Yokota,N Sasaki,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research

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Repair of ulnar segmental defect by recombinant human bone morphogenetic protein-2 in dogs. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of veterinary medical science / the Ja

VOLUME: 60

Page Numbers: 451-8

Journal Abbreviation: J. Vet. Med. Sci.

ISSN: 0916-7250

DAY: 19

MONTH: Apr

YEAR: 1998

Repair of ulnar segmental defect by recombinant human bone morphogenetic protein-2 in dogs. Information

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LANGUAGE: eng

NlmUniqueID: 9105360

Repair of ulnar segmental defect by recombinant human bone morphogenetic protein-2 in dogs. Keywords Mesh Terms:

KEYWORDS: Wound Healing

MESH TERMS: veterinary

Chemical & Substance for Abstract: Repair of ulnar segmental defect by recombinant human bone morphogenetic protein-2 in dogs. Information

Substance Name: Gelatin

Registry Number: 9000-70-8

Grant and Affiliation Information for Repair of ulnar segmental defect by recombinant human bone morphogenetic protein-2 in dogs.

AFFILIATION: Laboratory of Veterinary Surgery, Graduate School of Agriculture and Life Science, University of Tokyo, Japan.

Country: JAPAN

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MEDLINETA: J Vet Med Sci

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