Repair mechanism of DNA-protein cross-link damage in Escherichia coli.

Repair mechanism of DNA-protein cross-link damage in Escherichia coli. Research Abstract Details 

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Repair mechanism of DNA-protein cross-link damage in Escherichia coli. Abstract Text:

Toshiaki Nakano,Soh Morishita,Hiroaki Terato,Seung Pil Pack,Keisuke Makino,Hiroshi Ide,

DNA-protein cross-link (DPC) damage is produced by varieties of genotoxic agents such as ionizing radiation, UV light, aldehydes, and some chemotherapeutic compounds. DPCs would be harmful to cells since proteins immobilized on DNA strands could hamper DNA transactions in cells. However, it has not been clarified how DPCs are repaired in cells. In the present study, we prepared DNA substrates containing defined DPCs and tested them for repair enzymes. We also examined the sensitivity of Escherichia coli to DPC-inducing agents.

Repair mechanism of DNA-protein cross-link damage in Escherichia coli. Publishing Authors By Initials

T Nakano,S Morishita,H Terato,SP Pack,K Makino,H Ide,

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Repair mechanism of DNA-protein cross-link damage in Escherichia coli. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nucleic acids symposium series (2004)

VOLUME:

Page Numbers: 213-4

Journal Abbreviation: Nucleic Acids Symp Ser (Oxf)

ISSN: 1746-8272

DAY: 21

MONTH: 11

YEAR: 2007

Repair mechanism of DNA-protein cross-link damage in Escherichia coli. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Repair mechanism of DNA-protein cross-link damage in Escherichia coli.

AFFILIATION: Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima 739-8526, Japan.

Country: England

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MEDLINETA: Nucleic Acids Symp Ser (Oxf)

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