Renoprotective role of the vitamin D receptor in diabetic nephropathy.

Renoprotective role of the vitamin D receptor in diabetic nephropathy. Research Abstract Details 

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Renoprotective role of the vitamin D receptor in diabetic nephropathy. Abstract Text:

Z Zhang,L Sun,Y Wang,G Ning,A W Minto,J Kong,R J Quigg,Y C Li,Z Zhang,L Sun,Y Wang,G Ning,A W Minto,J Kong,R J Quigg,Y C Li,Z Zhang,L Sun,Y Wang,G Ning,A W Minto,J Kong,R J Quigg,Y C Li,

1,25-Dihydroxyvitamin D3 negatively regulates the renin-angiotensin system (RAS), which plays a critical role in the development of diabetic nephropathy. We tested if mice lacking the vitamin D receptor (VDR) are more susceptible to hyperglycemia-induced renal injury. Diabetic VDR knockout mice developed more severe albuminuria and glomerulosclerosis due to increased glomerular basement membrane thickening and podocyte effacement. More fibronectin (FN) and less nephrin were expressed in the VDR knockout mice compared to diabetic wild-type mice. In receptor knockout mice, increased renin, angiotensinogen, transforming growth factor-beta (TGF-beta), and connective tissue growth factor accompanied the more severe renal injury. 1,25-Dihydroxyvitmain D3 inhibited high glucose (HG)-induced FN production in cultured mesangial cells and increased nephrin expression in cultured podocytes. 1,25-Dihydroxyvitmain D3 also suppressed HG-induced activation of the RAS and TGF-beta in mesangial and juxtaglomerular cells. Our study suggests that receptor-mediated vitamin D actions are renoprotective in diabetic nephropathy.Kidney International (2008) 73, 163-171; doi:10.1038/sj.ki.5002572; published online 10 October 2007.

Renoprotective role of the vitamin D receptor in diabetic nephropathy. Publishing Authors By Initials

Z Zhang,L Sun,Y Wang,G Ning,AW Minto,J Kong,RJ Quigg,YC Li,Z Zhang,L Sun,Y Wang,G Ning,AW Minto,J Kong,RJ Quigg,YC Li,Z Zhang,L Sun,Y Wang,G Ning,AW Minto,J Kong,RJ Quigg,YC Li,

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Renoprotective role of the vitamin D receptor in diabetic nephropathy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Kidney international

VOLUME: 73

Page Numbers: 163-71

Journal Abbreviation: Kidney Int.

ISSN: 0085-2538

DAY: 10

MONTH: 10

YEAR: 2007

Renoprotective role of the vitamin D receptor in diabetic nephropathy. Information

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LANGUAGE: eng

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AFFILIATION: 1Division of Biological Sciences, Department of Medicine, The University of Chicago, Chicago, Illinois, USA.

Country: United States

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MEDLINETA: Kidney Int

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