Renin: at the heart of the mast cell.

Renin: at the heart of the mast cell. Research Abstract Details 

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Renin: at the heart of the mast cell. Abstract Text:

Alicia C Reid,Randi B Silver,Roberto Levi,

Cardiac mast cells proliferate in cardiovascular diseases. In myocardial ischemia, mast cell mediators contribute to coronary vasoconstriction, arrhythmias, leukocyte recruitment, and tissue injury and repair. Arrhythmic dysfunction, coronary vasoconstriction, and contractile failure are also characteristic of cardiac anaphylaxis. In coronary atherosclerosis, mast cell mediators facilitate cholesterol accumulation and plaque destabilization. In cardiac failure, mast cell chymase causes myocyte apoptosis and fibroblast proliferation, leading to ventricular dysfunction. Chymase and tryptase also contribute to fibrosis in cardiomyopathies and myocarditis. In addition, mast cell tumor necrosis factor-alpha promotes myocardial remodeling. Cardiac remodeling and hypertrophy in end-stage hypertension are also induced by mast cell mediators and proteases. We recently discovered that cardiac mast cells contain and release renin, which initiates local angiotensin formation. Angiotensin causes coronary vasoconstriction, arrhythmias, fibrosis, apoptosis, and endothelin release, all demonstrated mechanisms of mast-cell-associated cardiac disease. The effects of angiotensin are further amplified by the release of norepinephrine from cardiac sympathetic nerves. Our discovery of renin in cardiac mast cells and its release in pathophysiological conditions uncovers an important new pathway in the development of mast-cell-associated heart diseases. Several steps in this novel pathway may constitute future therapeutic targets.

Renin: at the heart of the mast cell. Publishing Authors By Initials

AC Reid,RB Silver,R Levi,

For similar enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: endopeptidases: aspartic endopeptidases: renin research abstracts see: enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: endopeptidases: aspartic endopeptidases: renin research

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Renin: at the heart of the mast cell. Journal Published:

PUBLICATION TYPE: Review

Journal: Immunological reviews

VOLUME: 217

Page Numbers: 123-40

Journal Abbreviation: Immunol. Rev.

ISSN: 0105-2896

DAY: 3

MONTH: Jun

YEAR: 2007

Renin: at the heart of the mast cell. Information

Number of References: 233

LANGUAGE: eng

NlmUniqueID: 7702118

Renin: at the heart of the mast cell. Keywords Mesh Terms:

KEYWORDS: Renin

MESH TERMS: metabolism

Chemical & Substance for Abstract: Renin: at the heart of the mast cell. Information

Substance Name: Renin

Registry Number: EC 3.4.23.15

Grant and Affiliation Information for Renin: at the heart of the mast cell.

AFFILIATION: Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY 10021, USA.

Country: Denmark

AGENCY: United States NHLBI

GRANT: HL73400

ACRONYM: HL

MEDLINETA: Immunol Rev

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