Renal Phosphodiesterase 4B Is Activated in the Dahl Salt-Sensitive Rat.

Renal Phosphodiesterase 4B Is Activated in the Dahl Salt-Sensitive Rat. Research Abstract Details 

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Renal Phosphodiesterase 4B Is Activated in the Dahl Salt-Sensitive Rat. Abstract Text:

Urmila Tawar,Kumar Kotlo,Shilpa Jain,Sagar Shukla,Suman Setty,Robert S Danziger,

Reduced beta-adrenoreceptor signaling is associated with increased sympathoadrenal activity in hypertensive patients and animal models of hypertension. However, the mechanism that accounts for this characteristic decline in beta-adrenergic signaling is unclear. In the present study, we investigated renal phosphodiesterase 4B, which metabolizes cAMP. Immunoblot analysis detected only the phosphodiesterase 4B4 isoform present in kidney tissue from spontaneously hypertensive rats, hypertensive Dahl salt-sensitive (SS) rats, and Dahl salt-resistant rats. The phosphorylated (activated) form of the protein was present at 2-fold greater levels in Dahl SS rats than in spontaneously hypertensive rats and Dahl salt-resistant rats, whereas the unphosphorylated form of the protein was reduced by approximately one half in SS animals. In accord with immunoblot data, rolipram-inhibitable cAMP hydrolyzing activity, a measure of PDE4 activity, was approximately 3-fold greater in kidney cytosolic extracts from SS rats than in extracts from spontaneously hypertensive rats and salt-resistant rats. Phosphodiesterase 4B expression was detected by immunohistochemistry in the renal vasculature, proximal tubules, and distal tubules. These results raise the possibility that increased PDE4 activity, specifically phosphodiesterase 4B4 activity, reduces beta-adrenergic signaling in the kidney and contributes to salt-sensitive hypertension in the Dahl SS rat.

Renal Phosphodiesterase 4B Is Activated in the Dahl Salt-Sensitive Rat. Publishing Authors By Initials

U Tawar,K Kotlo,S Jain,S Shukla,S Setty,RS Danziger,

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Renal Phosphodiesterase 4B Is Activated in the Dahl Salt-Sensitive Rat. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hypertension

VOLUME: 51

Page Numbers: 762-6

Journal Abbreviation: Hypertension

ISSN: 1524-4563

DAY: 28

MONTH: 01

YEAR: 2008

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LANGUAGE: eng

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AFFILIATION: Department of Medicine, University of Illinois at Chicago, 840 S Wood St, Chicago, IL 60612. rdanziger@aol.com.

Country: United States

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MEDLINETA: Hypertension

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