Renal hyaluronan content during experimental uncontrolled diabetes in rats.

Renal hyaluronan content during experimental uncontrolled diabetes in rats. Research Abstract Details 

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Renal hyaluronan content during experimental uncontrolled diabetes in rats. Abstract Text:

With diabetes mellitus, the ability of the kidneys to maintain fluid balance is affected. Hyperglycaemia increases production of hyaluronan in cultured kidney cells implying that diabetes promotes induction of hyaluronan in the kidney. The aim of the present study was to determine if the interstitial matrix component hyaluronan is differently distributed within the kidney in diabetic rats compared to non-diabetic rats. Furthermore, to test if diabetic rats are able to respond with diuresis upon a hypotonic fluid load. The normal heterogeneous intrarenal distribution of hyaluronan was confirmed in non-diabetic control rats, with 60-fold more in the papilla than in the cortex. In diabetic animals, the cortical hyaluronan was unaffected but the papillary hyaluronan content was 3-fold higher than in non-diabetic rats. This increase correlated with a more than three-fold induction of the papillary hyaluronan-synthase 2 mRNA expression. In non-diabetic animals, 2 h water loading increased papillary hyaluronan (+93%) and diuresis (17-fold). In diabetic animals, baseline diuresis was 8-fold higher than in non-diabetic animals, which correlated with hyperglycaemia, glucosuria and proteinuria. Water loading in diabetic animals did not further increase papillary hyaluronan or diuresis: the urine flow rate decreased. To conclude, papillary hyaluronan is elevated in diabetic rats, which coincides with induction of hyaluronan-synthase 2 mRNA, hyperglycaemia, glucosuria, proteinuria and overt diuresis. The inability to respond to a water load with further diuresis may be related to the already elevated papillary hyaluronan and the inability to change hyaluronan during water loading.

Renal hyaluronan content during experimental uncontrolled diabetes in rats. Publishing Authors By Initials

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Renal hyaluronan content during experimental uncontrolled diabetes in rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of physiology and pharmacology : an offici

VOLUME: 59

Page Numbers: 115-28

Journal Abbreviation: J. Physiol. Pharmacol.

ISSN: 0867-5910

DAY: 28

MONTH: Mar

YEAR: 2008

Renal hyaluronan content during experimental uncontrolled diabetes in rats. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Renal hyaluronan content during experimental uncontrolled diabetes in rats.

AFFILIATION: Division of Integrative Physiology, Department of Medical Cell Biology, Uppsala University, S-751 23 Uppsala, Sweden. Louise.Rugheimer@mcb.uu.se

Country: Poland

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MEDLINETA: J Physiol Pharmacol

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