Renal function measurements from MR renography and a simplified multicompartmental model.

Renal function measurements from MR renography and a simplified multicompartmental model. Research Abstract Details 

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Renal function measurements from MR renography and a simplified multicompartmental model. Abstract Text:

Vivian S Lee,Henry Rusinek,Louisa Bokacheva,Ambrose J Huang,Niels Oesingmann,Qun Chen,Manmeen Kaur,Keyma Prince,Ting Song,Elissa L Kramer,Edward F Leonard,

The purpose of this study was to determine the accuracy and sources of error in estimating single-kidney glomerular filtration rate (GFR) derived from low-dose gadolinium-enhanced T1-weighted MR renography. To analyze imaging data, MR signal intensity curves were converted to concentration vs. time curves, and a three-compartment, six-parameter model of the vascular-nephron system was used to analyze measured aortic, cortical, and medullary enhancement curves. Reliability of the parameter estimates was evaluated by sensitivity analysis and by Monte Carlo analyses of model solutions to which random noise had been added. The dominant sensitivity of the medullary enhancement curve to GFR 1-4 min after tracer injection was supported by a low coefficient of variation in model-fit GFR values (4%) when measured data were subjected to 5% noise. These analyses also showed the minimal effects of bolus dispersion in the aorta on parameter reliability. Single-kidney GFR from MR renography analyzed by the three-compartment model (4.0-71.4 ml/min) agreed well with reference measurements from (99m)Tc-DTPA clearance and scintigraphy (r = 0.84, P < 0.001). Bland-Altman analysis showed an average difference of 11.9 ml/min (95% confidence interval = 5.8-17.9 ml/min) between model and reference values. We conclude that a nephron-based multicompartmental model can be used to derive clinically useful estimates of single-kidney GFR from low-dose MR renography.

Renal function measurements from MR renography and a simplified multicompartmental model. Publishing Authors By Initials

VS Lee,H Rusinek,L Bokacheva,AJ Huang,N Oesingmann,Q Chen,M Kaur,K Prince,T Song,EL Kramer,EF Leonard,

For similar investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research

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Renal function measurements from MR renography and a simplified multicompartmental model. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of physiology. Renal physiology

VOLUME: 292

Page Numbers: F1548-59

Journal Abbreviation:

ISSN: 0363-6127

DAY: 9

MONTH: 01

YEAR: 2007

Renal function measurements from MR renography and a simplified multicompartmental model. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901990

Renal function measurements from MR renography and a simplified multicompartmental model. Keywords Mesh Terms:

KEYWORDS: Sensitivity and Specificity

MESH TERMS: physiology

Chemical & Substance for Abstract: Renal function measurements from MR renography and a simplified multicompartmental model. Information

Substance Name: Gadolinium

Registry Number: 7440-54-2

Grant and Affiliation Information for Renal function measurements from MR renography and a simplified multicompartmental model.

AFFILIATION: Department of Radiology, New York University School of Medicine, Columbia University, New York, New York 10016, USA. vivian.lee@med.nyu.edu

Country: United States

AGENCY: United States NIDDK

GRANT: DK-063183

ACRONYM: DK

MEDLINETA: Am J Physiol Renal Physiol

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