Renal disease in an antiretroviral-naïve HIV-infected outpatient population in Western Kenya.

Renal disease in an antiretroviral-naïve HIV-infected outpatient population in Western Kenya. Research Abstract Details 

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Renal disease in an antiretroviral-naïve HIV-infected outpatient population in Western Kenya. Abstract Text:

BACKGROUND: Several commonly used antiretrovirals (ARVs) require dose adjustments to prevent toxicities in the presence of renal insufficiency. Because no prospective studies of the prevalence or risk factors for kidney disease in stable outpatient human immunodeficiency virus (HIV)-infected indigenous African populations have been published to date, it is not known if already scarce resources should be allocated to detect renal dysfunction, in those without risk factors for kidney disease, prior to initiation of increasingly available antiretrovirals in developing countries. METHODS: A cross-sectional study to determine the prevalence of and risk factors for renal disease in a cohort of medically stable, HIV-infected, antiretroviral-naïve adults, without diabetes or hypertension, presenting to an HIV clinic in western Kenya. RESULTS: Of 373 patients with complete data, renal insufficiency (CrCl <60 ml/min) was identified in 43 (11.5%) [18 (4.8%) had a CrCl <50 ml/min]. Despite high correlation coefficients between the three renal function estimating equations used, when compared to creatinine clearance as calculated by Cockcroft-Gault, lower rates of moderate to severe renal insufficiency were identified by the Modification of Diet in Renal Disease equations. Proteinuria, defined as a urine dipstick protein of equal to or greater than 1+, was detected in only 23 subjects (6.2%). CONCLUSIONS: Renal insufficiency is not uncommon, even in stable patients without diabetes or hypertension. Conversely, proteinuria was unexpectedly infrequent in this population. Utilizing resources to assess renal function prior to initiation of antiretrovirals in order to identify those likely to benefit from dosage adjustment is justified.

Renal disease in an antiretroviral-naïve HIV-infected outpatient population in Western Kenya. Publishing Authors By Initials

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research

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Renal disease in an antiretroviral-naïve HIV-infected outpatient population in Western Kenya. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nephrology, dialysis, transplantation : official p

VOLUME: 22

Page Numbers: 2208-12

Journal Abbreviation: Nephrol. Dial. Transplant.

ISSN: 0931-0509

DAY: 3

MONTH: Aug

YEAR: 2007

Renal disease in an antiretroviral-naïve HIV-infected outpatient population in Western Kenya. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8706402

Renal disease in an antiretroviral-naïve HIV-infected outpatient population in Western Kenya. Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: diagnosis

Chemical & Substance for Abstract: Renal disease in an antiretroviral-naïve HIV-infected outpatient population in Western Kenya. Information

Substance Name: Creatine

Registry Number: 57-00-1

Grant and Affiliation Information for Renal disease in an antiretroviral-naïve HIV-infected outpatient population in Western Kenya.

AFFILIATION: Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Country: England

AGENCY: United States NHLBI

GRANT: K23 HL-073682

ACRONYM: HL

MEDLINETA: Nephrol Dial Transplant

REFSOURCE: Nephrol Dial Transplant. 2007 Aug;22(8):

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