Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice.

Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice. Research Abstract Details 

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Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice. Abstract Text:

Olav Olsen,Lars Funke,Jia-fu Long,Masaki Fukata,Toshinari Kazuta,Jonathan C Trinidad,Kimberly A Moore,Hidemi Misawa,Paul A Welling,Alma L Burlingame,Mingjie Zhang,David S Bredt,Olav Olsen,Lars Funke,Jia-fu Long,Masaki Fukata,Toshinari Kazuta,Jonathan C Trinidad,Kimberly A Moore,Hidemi Misawa,Paul A Welling,Alma L Burlingame,Mingjie Zhang,David S Bredt,Olav Olsen,Lars Funke,Jia-fu Long,Masaki Fukata,Toshinari Kazuta,Jonathan C Trinidad,Kimberly A Moore,Hidemi Misawa,Paul A Welling,Alma L Burlingame,Mingjie Zhang,David S Bredt,

Kidney development and physiology require polarization of epithelia that line renal tubules. Genetic studies show that polarization of invertebrate epithelia requires the crumbs, partition-defective-3, and discs large complexes. These evolutionarily conserved protein complexes occur in mammalian kidney; however, their role in renal development remains poorly defined. Here, we find that mice lacking the small PDZ protein mammalian LIN-7c (MALS-3) have hypomorphic, cystic, and fibrotic kidneys. Proteomic analysis defines MALS-3 as the only known core component of both the crumbs and discs large cell polarity complexes. MALS-3 mediates stable assembly of the crumbs tight junction complex and the discs large basolateral complex, and these complexes are disrupted in renal epithelia from MALS-3 knockout mice. Interestingly, MALS-3 controls apico-basal polarity preferentially in epithelia derived from metanephric mesenchyme, and defects in kidney architecture owe solely to MALS expression in these epithelia. These studies demonstrate that defects in epithelial cell polarization can cause cystic and fibrotic renal disease.

Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice. Publishing Authors By Initials

O Olsen,L Funke,JF Long,M Fukata,T Kazuta,JC Trinidad,KA Moore,H Misawa,PA Welling,AL Burlingame,M Zhang,DS Bredt,O Olsen,L Funke,JF Long,M Fukata,T Kazuta,JC Trinidad,KA Moore,H Misawa,PA Welling,AL Burlingame,M Zhang,DS Bredt,O Olsen,L Funke,JF Long,M Fukata,T Kazuta,JC Trinidad,KA Moore,H Misawa,PA Welling,AL Burlingame,M Zhang,DS Bredt,

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Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of cell biology

VOLUME: 179

Page Numbers: 151-64

Journal Abbreviation: J. Cell Biol.

ISSN: 0021-9525

DAY: 8

MONTH: Oct

YEAR: 2007

Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice. Information

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LANGUAGE: eng

NlmUniqueID: 375356

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AFFILIATION: Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA. olav.olsen@ucsf.edu

Country: United States

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MEDLINETA: J Cell Biol

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