Renal bone disorders in children: therapy with vitamin D3 or 1,25-dihydroxycholecalciferol.

Renal bone disorders in children: therapy with vitamin D3 or 1,25-dihydroxycholecalciferol. Research Abstract Details 

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Renal bone disorders in children: therapy with vitamin D3 or 1,25-dihydroxycholecalciferol. Abstract Text:

M Bulla,G Delling,G Offermann,R Ziegler,G Benz,H Lühmann,A Sanchez de Reutter,M Severin,

Twelve children with chronic renal failure (CRF) and sixteen children receiving regular dialysis therapy (RDT) were treated with between 10,000 and 50,000 IU of vitamin D daily. This was associated with an increase in serum calcium levels and reduction in PTH levels. In the children with CRF, secondary hyperparathyroidism was improved with treatment but its development was not completely prevented nor was healing complete. In the patients receiving RDT, treatment with vitamin D improved the changes associated with secondary hyperparathyroidism in 50% of cases but these features sometimes reappeared despite continuing treatment. Hypercalcaemia or metastatic calcification was not seen. Subsequently, 1,25(OH)2D3 was administered to 14 children receiving RDT. This was associated with the return of serum calcium levels to normal, inhibition of PTH synthesis and an improvement in intestinal calcium absorption. Fibro-osteoclasia was cured and there was improvement in actual bone resorption. There was also improvement in osteoidosis in those children who showed disturbances of mineralisation. Calcification in the limbus area of the eyes may occur and hypercalcaemia was seen commonly. Treatment with 1,25(OH)2D3 should only be offered to children with severe renal bone disease. Neither vitamin D3 nor 1,25(OH)2D3 can guarantee complete recovery of osteodystrophy and of growth arrest in uraemic children.

Renal bone disorders in children: therapy with vitamin D3 or 1,25-dihydroxycholecalciferol. Publishing Authors By Initials

M Bulla,G Delling,G Offermann,R Ziegler,G Benz,H Lühmann,A Sanchez de Reutter,M Severin,

For similar therapeutics: renal replacement therapy: renal dialysis research abstracts see: therapeutics: renal replacement therapy: renal dialysis research

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Renal bone disorders in children: therapy with vitamin D3 or 1,25-dihydroxycholecalciferol. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Proceedings of the European Dialysis and Transplan

VOLUME: 16

Page Numbers: 644-8

Journal Abbreviation:

ISSN: 0071-2736

DAY: 21

MONTH: 02

YEAR: 1979

Renal bone disorders in children: therapy with vitamin D3 or 1,25-dihydroxycholecalciferol. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 355210

Renal bone disorders in children: therapy with vitamin D3 or 1,25-dihydroxycholecalciferol. Keywords Mesh Terms:

KEYWORDS: Renal Dialysis

MESH TERMS: blood

Chemical & Substance for Abstract: Renal bone disorders in children: therapy with vitamin D3 or 1,25-dihydroxycholecalciferol. Information

Substance Name: Alkaline Phosphatase

Registry Number: EC 3.1.3.1

Grant and Affiliation Information for Renal bone disorders in children: therapy with vitamin D3 or 1,25-dihydroxycholecalciferol.

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Country: ENGLAND

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MEDLINETA: Proc Eur Dial Transplant Assoc

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