Remarkable functional aspects of myoglobin induced by diazaheme prosthetic group.

Remarkable functional aspects of myoglobin induced by diazaheme prosthetic group. Research Abstract Details 

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Remarkable functional aspects of myoglobin induced by diazaheme prosthetic group. Abstract Text:

S Neya,H Hori,K Imai,Y Kawamura-Konishi,H Suzuki,Y Shiro,T Iizuka,N Funasaki,

The iron complex of beta,delta-diazamesoporphyrin III, a molecular hybrid of porphyrin and phthalocyanine, was incorporated into apomyoglobin to investigate novel biological aspects of myoglobin. The reconstituted ferric protein forms an internal hemichrome with the iron-bound distal histidine. The reduced ferrous protein has extraordinarily high affinities for O2 and CO. The ferrous myoglobin is capable of strong binding with pyridine, imidazole, cyanide, and azide, and reacts moderately with ammonia. The NO complex exhibited 5-coordinate to 6-coordinate transition over 150 min. The instability of 5-coordinate NO heme is consistent with a high affinity of imidazole to the ferrous heme. The kinetic analyses of the ferrous derivatives suggest the importance of the pi orbitals in neutral ligands as well as the negative charges in anionic ligands. A high affinity of imidazole to ferrous diazaheme accounts for the internal hemochrome formation in ferrous myoglobin containing phthalocyanines.

Remarkable functional aspects of myoglobin induced by diazaheme prosthetic group. Publishing Authors By Initials

S Neya,H Hori,K Imai,Y Kawamura-Konishi,H Suzuki,Y Shiro,T Iizuka,N Funasaki,

For similar heterocyclic compounds: heterocyclic compounds, 1-ring: azoles: pyrroles: tetrapyrroles: porphyrins research abstracts see: heterocyclic compounds: heterocyclic compounds, 1-ring: azoles: pyrroles: tetrapyrroles: porphyrins research

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Remarkable functional aspects of myoglobin induced by diazaheme prosthetic group. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 121

Page Numbers: 654-60

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Apr

YEAR: 1997

Remarkable functional aspects of myoglobin induced by diazaheme prosthetic group. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Remarkable functional aspects of myoglobin induced by diazaheme prosthetic group. Keywords Mesh Terms:

KEYWORDS: Porphyrins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Remarkable functional aspects of myoglobin induced by diazaheme prosthetic group. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Remarkable functional aspects of myoglobin induced by diazaheme prosthetic group.

AFFILIATION: Department of Physical Chemistry, Kyoto Pharmaceutical University, Yamashina-ku.

Country: JAPAN

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MEDLINETA: J Biochem

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