Reliability, validity, and minimally important differences of the SF-6D in systemic sclerosis.

Reliability, validity, and minimally important differences of the SF-6D in systemic sclerosis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Reliability, validity, and minimally important differences of the SF-6D in systemic sclerosis. Abstract Text:

Dinesh Khanna,Daniel E Furst,Weng Kee Wong,Joel Tsevat,Philip J Clements,Grace S Park,Arnold E Postlethwaite,Mansoor Ahmed,Shaari Ginsburg,Ron D Hays, ,

OBJECTIVES: To evaluate the reliability and validity and estimate the minimally important difference (MID) for the SF-6D in patients with systemic sclerosis (SSc). Subjects We used data from two clinical studies to analyze the SF-6D in patients with SSc: Study 1 was a cross-sectional observational study (N = 107) designed to assess three direct preference measures--the rating scale, time trade-off, and standard gamble (SG) in patients with diffuse SSc and limited SSc, and Study 2 was a 12-month randomized, placebo-controlled, clinical trial (N = 168) assessing oral bovine collagen versus placebo in diffuse SSc. METHODS: We assessed the test-retest reliability of the SF-6D in Study 2 over a mean (SD) 4.8 (3.0)-week interval and the agreement between the SF-6D and direct preference measures in Study 1 using intraclass correlations (ICC). The MID was estimated using three different anchors--the SF-36 change in health item (patients who answered "somewhat better" formed the MID group), the Health Assessment Questionnaire-Disability Index (HAQ-DI; change of > or =0.14 and > or =0.22) and the skin score (change of > or =5.3). Results The mean (SD) SF-6D scores were 0.61 (0.12) in Study 1 and 0.64 (0.13) in Study 2. Test-retest reliability for the SF-6D was high (ICC = 0.82 [95% CI: 0.76, 0.87]). Agreement between the SF-6D and three direct preferences measures was poor to moderate (0.16-0.52). The MID estimate for the SF-6D using the change in SF-36 item -0.012 and this level of change was similar to the no change group. The mean MID estimate for the SF-6D improvement using the HAQ-DI and skin score as anchors was 0.035 (effect size of 0.27). CONCLUSION: This is the first study to assess the SF-6D in SSc. The SF-6D is reliable and valid in patients with SSc. We provide MID estimates that can aid in calculating sample size for clinical trials involving patients with diffuse SSc.

Reliability, validity, and minimally important differences of the SF-6D in systemic sclerosis. Publishing Authors By Initials

D Khanna,DE Furst,WK Wong,J Tsevat,PJ Clements,GS Park,AE Postlethwaite,M Ahmed,S Ginsburg,RD Hays, ,

For similar geographic locations: americas: north america: united states research abstracts see: geographic locations: americas: north america: united states research

PUBMED ID PMID:

MEDLINE DATE:

Reliability, validity, and minimally important differences of the SF-6D in systemic sclerosis. Journal Published:

PUBLICATION TYPE: Validation Studies

Journal: Quality of life research : an international journa

VOLUME: 16

Page Numbers: 1083-92

Journal Abbreviation:

ISSN: 0962-9343

DAY: 3

MONTH: 04

YEAR: 2007

Reliability, validity, and minimally important differences of the SF-6D in systemic sclerosis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9210257

Reliability, validity, and minimally important differences of the SF-6D in systemic sclerosis. Keywords Mesh Terms:

KEYWORDS: United States

MESH TERMS: psychology

Chemical & Substance for Abstract: Reliability, validity, and minimally important differences of the SF-6D in systemic sclerosis. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for Reliability, validity, and minimally important differences of the SF-6D in systemic sclerosis.

AFFILIATION: Division of Immunology, Department of Internal Medicine, University of Cincinnati Medical Center, PO Box 670563, Cincinnati, OH 45267-0563, USA. dinesh.khanna@uc.edu

Country: Netherlands

AGENCY: United States NCMHD

GRANT: P20-MD00148-01

ACRONYM: MD

MEDLINETA: Qual Life Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Reliability, validity, and minimally important differences of the SF-6D in systemic sclerosis Related Publications

• A mechanism-based cancer risk assessment for 1,4-dichlorobenzene.
• Acute effects of cocaine in two models of inhibitory control: implications of non-linear dose effects.
• Cognitive-behavioural treatment for men with intellectual disabilities and sexually abusive behaviour: a pilot study.
• Correlated physical and mental health summary scores for the SF-36 and SF-12 Health Survey, V.I.
• Developing a Spanish-language consumer report for CAHPS health plan surveys.
• Direct observation of regulated ribonucleoprotein transport across the nurse cell/oocyte boundary.
• Discrimination between wild-type and ampicillin-resistant Escherichia coli by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
• Doppler line profile analysis for a multichannel Fabry-Perot interferometer.
• Drusilla rageu poole 1921-1981.
• Effect of halogenated ethylamines on cardiac arrhythmias induced by epinephrine, nicotine and cyclopropane.
• Human DNA mismatch repair: coupling of mismatch recognition to strand-specific excision.
• Human monoclonal IgM anti-Gal(beta 1-3)GalNAc autoantibodies bind to the surface of bovine spinal motoneurons.
• Localization of GM1 and Gal(beta 1-3)GalNAc antigenic determinants in peripheral nerve.
• Localization of neural epitopes that bind to IgM monoclonal autoantibodies (M-proteins) from two patients with motor neuron disease.
• Lost in translation.
• Manifest refraction.
• Mitochondrial membrane depolarization in Drosophila apoptosis.
• On the cover.
• Parenteral thyroxine administration.
• Pressurized oxygen therapy; final report of a new method.
• Reaching East.
• Reforming medical education in the United Kingdom: lessons for Australia and New Zealand.
• Reliability, validity, and minimally important differences of the SF-6D in systemic sclerosis.
• Retention of B vitamins after large-scale cooking of meat; suitability of left and right muscles for retention studies.
• Retention of B vitamins in beef and veal after home canning and storage.
• Role of oxidative stress in arsenic-induced toxicity.
• Solving the puzzle of hormone replacement.
• The SF-36 physical and mental health factors were confirmed in cancer and HIV/AIDS patients.
• The role of the bifactor model in resolving dimensionality issues in health outcomes measures.
• What is sufficient evidence for the reliability and validity of patient-reported outcome measures?