Relevance of seizure-induced neurogenesis in animal models of epilepsy to the etiology of temporal lobe epilepsy.

Relevance of seizure-induced neurogenesis in animal models of epilepsy to the etiology of temporal lobe epilepsy. Research Abstract Details 

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Relevance of seizure-induced neurogenesis in animal models of epilepsy to the etiology of temporal lobe epilepsy. Abstract Text:

Helen E Scharfman,William P Gray,

Seizure induction in laboratory animals is followed by many changes in structure and function, and one of these is an increase in neurogenesis-the birth of new neurons. This phenomenon may be relevant to temporal lobe epilepsy (TLE), because one of the regions of the brain where seizure-induced neurogenesis is most robust is the dentate gyrus-an area of the brain that has been implicated in the pathophysiology of TLE. Although initial studies predicted that neurogenesis in the dentate gyrus would be important to normal functions, such as learning and memory, the new neurons that are born after seizures may not necessarily promote normal function. There appears to be a complex functional and structural relationship between the new dentate gyrus neurons and preexisting cells, both in the animal models of TLE and in tissue resected from patients with intractable TLE. These studies provide new insights into the mechanisms of TLE, and suggest novel strategies for intervention that could be used to prevent or treat TLE.

Relevance of seizure-induced neurogenesis in animal models of epilepsy to the etiology of temporal lobe epilepsy. Publishing Authors By Initials

HE Scharfman,WP Gray,

For similar nervous system diseases: central nervous system diseases: brain diseases: epilepsy: status epilepticus research abstracts see: nervous system diseases: central nervous system diseases: brain diseases: epilepsy: status epilepticus research

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Relevance of seizure-induced neurogenesis in animal models of epilepsy to the etiology of temporal lobe epilepsy. Journal Published:

PUBLICATION TYPE: Review

Journal: Epilepsia

VOLUME: 48 Suppl 2

Page Numbers: 33-41

Journal Abbreviation: Epilepsia

ISSN: 0013-9580

DAY: 3

MONTH: 12

YEAR: 2007

Relevance of seizure-induced neurogenesis in animal models of epilepsy to the etiology of temporal lobe epilepsy. Information

Number of References: 81

LANGUAGE: eng

NlmUniqueID: 2983306

Relevance of seizure-induced neurogenesis in animal models of epilepsy to the etiology of temporal lobe epilepsy. Keywords Mesh Terms:

KEYWORDS: Status Epilepticus

MESH TERMS: physiopathology

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Grant and Affiliation Information for Relevance of seizure-induced neurogenesis in animal models of epilepsy to the etiology of temporal lobe epilepsy.

AFFILIATION: Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, New York State Department of Health, West Haverstraw, New York 10993-1195, USA. scharfmanh@helenhayeshopsp.org

Country: United States

AGENCY: United States NINDS

GRANT: NS 41490

ACRONYM: NS

MEDLINETA: Epilepsia

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