Release of doxorubicin from unstabilized and stabilized micelles under the action of ultrasound.

Release of doxorubicin from unstabilized and stabilized micelles under the action of ultrasound. Research Abstract Details 

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Release of doxorubicin from unstabilized and stabilized micelles under the action of ultrasound. Abstract Text:

Ghaleb A Husseini,Mario A Diaz de la Rosa,Tasneem Gabuji,Yi Zeng,Douglas A Christensen,William G Pitt,

Polymeric micelles are being investigated as chemotherapy drug delivery carriers using ultrasound as a trigger mechanism. The aim of this paper is to measure the release of Doxorubicin (Dox) from the core of unstabilized Pluronic P105 micelles, Pluronic P105 micelles stabilized with an interpenetrating network of N,N-diethylacrylamide, and micelles of poly(ethylene oxide)-b-poly (N-isopropylacrylamide)-b-poly(oligolactylmethacrylate) with stabilized cores. An ultrasonic exposure chamber with fluorescence detection was used to measure the release of the antineoplastic agent from both stabilized and unstabilized micelles. The release of Dox at 37 degrees C from unstabilized Pluronic appears to be several times higher than release from the more stabilized and crosslinked copolymers at the same temperature. Although there is a difference in the amount of release between the different compounds, the onset of release occurs at about the same ultrasonic power density for all carriers investigated in this study. The threshold of drug release for all the compounds correlates to the emergence of subharmonic peaks detected in the acoustic spectra. We hypothesize that shearing events caused by cavitating bubbles play an important role in the acoustically activated release of chemotherapy agents delivered from various polymeric drug delivery vehicles.

Release of doxorubicin from unstabilized and stabilized micelles under the action of ultrasound. Publishing Authors By Initials

GA Husseini,MA Diaz de la Rosa,T Gabuji,Y Zeng,DA Christensen,WG Pitt,

For similar natural sciences: physics: acoustics: ultrasonics research abstracts see: natural sciences: physics: acoustics: ultrasonics research

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Release of doxorubicin from unstabilized and stabilized micelles under the action of ultrasound. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of nanoscience and nanotechnology

VOLUME: 7

Page Numbers: 1028-33

Journal Abbreviation:

ISSN: 1533-4880

DAY: 3

MONTH: Mar

YEAR: 2007

Release of doxorubicin from unstabilized and stabilized micelles under the action of ultrasound. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101088195

Release of doxorubicin from unstabilized and stabilized micelles under the action of ultrasound. Keywords Mesh Terms:

KEYWORDS: Ultrasonics

MESH TERMS: chemistry

Chemical & Substance for Abstract: Release of doxorubicin from unstabilized and stabilized micelles under the action of ultrasound. Information

Substance Name: Doxorubicin

Registry Number: 23214-92-8

Grant and Affiliation Information for Release of doxorubicin from unstabilized and stabilized micelles under the action of ultrasound.

AFFILIATION: Chemical Engineering Department, American University of Sharjah, Sharjah, United Arab Emirates.

Country: United States

AGENCY: United States NCI

GRANT: R01 CA98138

ACRONYM: CA

MEDLINETA: J Nanosci Nanotechnol

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