Release and recycling of the readily releasable vesicle population in a synapse possessing no reserve population.

Release and recycling of the readily releasable vesicle population in a synapse possessing no reserve population. Research Abstract Details 

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Release and recycling of the readily releasable vesicle population in a synapse possessing no reserve population. Abstract Text:

J H Koenig,Kazuo Ikeda,

We previously demonstrated that the tergotrochanteral muscle (TTM) of Drosophila is innervated by unique synapses that possess a small readily releasable/recycling vesicle population (active zone population), but not the larger reserve vesicle population observed at other neuromuscular junctions in this animal. Using light and electron microscopic techniques and intracellular recording from the G1 muscle fiber of the TTM, the release and recycling characteristics of the readily releasable/recycling population were observed without any possible contribution from a reserve population. Our results indicate 1) the total number of vesicles in synapses presynaptic to the G1 fiber correlates with the total number of quanta that can be released onto this fiber; 2) the number of quanta released by a single action potential onto the G1 fiber is about one half the number of morphologically "docked" vesicles in active zones onto the G1, and this ratio decreases in a partially depleted state; 3) the recycling rate at 1-Hz stimulation, a frequency that does not cause any depression, is 0.24 recycled vesicle/active zone/s; and 4) normal-appearing spontaneous release occurs from the active zone vesicle population and, unlike synapses that possess a reserve population, the frequency of this release is reduced after high-frequency evoked activity.

Release and recycling of the readily releasable vesicle population in a synapse possessing no reserve population. Publishing Authors By Initials

JH Koenig,K Ikeda,

For similar nervous system: synapses: synaptic vesicles research abstracts see: nervous system: synapses: synaptic vesicles research

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Release and recycling of the readily releasable vesicle population in a synapse possessing no reserve population. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of neurophysiology

VOLUME: 97

Page Numbers: 4048-57

Journal Abbreviation: J. Neurophysiol.

ISSN: 0022-3077

DAY: 28

MONTH: 03

YEAR: 2007

Release and recycling of the readily releasable vesicle population in a synapse possessing no reserve population. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375404

Release and recycling of the readily releasable vesicle population in a synapse possessing no reserve population. Keywords Mesh Terms:

KEYWORDS: Synaptic Vesicles

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Release and recycling of the readily releasable vesicle population in a synapse possessing no reserve population. Information

Substance Name: Dynamins

Registry Number: EC 3.6.5.5

Grant and Affiliation Information for Release and recycling of the readily releasable vesicle population in a synapse possessing no reserve population.

AFFILIATION: Division of Neuroscience, Beckman Research Institute of the City of Hope, 1450 E. Duarte Rd., Duarte, CA 91010, USA. jkoenig@coh.org

Country: United States

AGENCY: United States NINDS

GRANT: NS-18856

ACRONYM: NS

MEDLINETA: J Neurophysiol

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