Relaxed selection among duplicate floral regulatory genes in Lamiales.

Relaxed selection among duplicate floral regulatory genes in Lamiales. Research Abstract Details 

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Relaxed selection among duplicate floral regulatory genes in Lamiales. Abstract Text:

Jan E Aagaard,John H Willis,Patrick C Phillips,

Polyploidization is a prevalent mode of genome diversification within plants. Most gene duplicates arising from polyploidization (paralogs) are typically lost, although a subset may be maintained under selection due to dosage, partitioning of gene function, or acquisition of novel functions. Because they experience selection in the presence of other duplicate loci across the genome, interactions among genes may also play a significant role in the maintenance of paralogs resulting from polyploidization. Previously, we identified duplicates of the genes LFY/FLO and AP3/DEF that directly interact in a floral regulatory pathway and are thought to be the result of ancient polyploidization in the Lamiales (> 50 mya). Although duplicates of MADS box genes including AP3/DEF are common throughout the angiosperm lineage, LFY/FLO duplicates in Lamiales are the first reported outside of tetraploid taxa. In order to explore hypotheses for the joint preservation of these interacting floral regulatory genes including novel LFY/FLO paralogs, here we clone FLO and DEF duplicates from additional Lamiales taxa and apply codon substitution models to test how selection acts on both genes following duplication. We find acceleration in the ratio of nonsynonymous-to-synonymous nucleotide substitutions for one (FLO) or both (DEF) paralogs that appears to be due to relaxed purifying selection as opposed to positive selection and shows a different pattern among functional domains of these genes. Several mechanisms are discussed that might be responsible for preservation of co-orthologs of FLO and DEF in Lamiales, including interactions among the genes of this regulatory pathway.

Relaxed selection among duplicate floral regulatory genes in Lamiales. Publishing Authors By Initials

JE Aagaard,JH Willis,PC Phillips,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Relaxed selection among duplicate floral regulatory genes in Lamiales. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of molecular evolution

VOLUME: 63

Page Numbers: 493-503

Journal Abbreviation: J. Mol. Evol.

ISSN: 0022-2844

DAY: 4

MONTH: 10

YEAR: 2006

Relaxed selection among duplicate floral regulatory genes in Lamiales. Information

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LANGUAGE: eng

NlmUniqueID: 360051

Relaxed selection among duplicate floral regulatory genes in Lamiales. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

Chemical & Substance for Abstract: Relaxed selection among duplicate floral regulatory genes in Lamiales. Information

Substance Name: Arabidopsis Proteins

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Grant and Affiliation Information for Relaxed selection among duplicate floral regulatory genes in Lamiales.

AFFILIATION: Center for Ecology and Evolutionary Biology, University of Oregon, Eugene, OR 97403, USA. jaagaard@gs.washington.edu

Country: Germany

AGENCY: United States NIGMS

GRANT: GM54185

ACRONYM: GM

MEDLINETA: J Mol Evol

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