[Relative study of soluble syndecan-1 and prognosis of patients with multiple myeloma]

[Relative study of soluble syndecan-1 and prognosis of patients with multiple myeloma] Research Abstract Details 

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[Relative study of soluble syndecan-1 and prognosis of patients with multiple myeloma] Abstract Text:

X Li,X Zhang,Z Lu,B Klein,

OBJECTIVE: To investigate the role of soluble syndecan-1 in the pathogenesis of human multiple myeloma (MM). METHODS: Serum level of soluble syndecan-1 of patients with MM and plasma cell leukemia was determined by ELISA. RESULTS: (1) The median serum soluble syndecan-1 concentrations of MM patients and controls were 111 ng/ml (41 - 6,300 mg/L) and 63 mg/L (10 - 163 mg/L), respectively (P < 0.005). (2) For 47 myeloma patients, increased serum syndecan-1 concentrations at diagnosis were associated with a poor prognosis. Patients with serum syndecan-1 levels below or above 166 mg/L had significantly different survival times (median > 48 months or < 18 months, respectively, P < 0.0001). (3) Serum soluble syndecan-1 levels were correlated with beta-2 microglobulin concentrations and the percentage of plasma cell. CONCLUSION: Serum levels of circulating soluble syndecan-1 correlated with tumor mass and may exert pleiotropic effects on myeloma cell behavior.

[Relative study of soluble syndecan-1 and prognosis of patients with multiple myeloma] Publishing Authors By Initials

X Li,X Zhang,Z Lu,B Klein,

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[Relative study of soluble syndecan-1 and prognosis of patients with multiple myeloma] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 22

Page Numbers: 303-5

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 5

MONTH: Jun

YEAR: 2001

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LANGUAGE: chi

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AFFILIATION: Institute of Medical Biotechnology, Suzhou University, Suzhou 215007, China.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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