Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1 alpha-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxylase in endometriosis and gynecologic cancers.

Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1 alpha-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxylase in endometriosis and gynecologic cancers. Research Abstract Details 

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Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1 alpha-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxylase in endometriosis and gynecologic cancers. Abstract Text:

Admir Agic,Hong Xu,Christopher Altgassen,Frank Noack,Monika M Wolfler,Klaus Diedrich,Michael Friedrich,Robert N Taylor,Daniela Hornung,Admir Agic,Hong Xu,Christopher Altgassen,Frank Noack,Monika M Wolfler,Klaus Diedrich,Michael Friedrich,Robert N Taylor,Daniela Hornung,Admir Agic,Hong Xu,Christopher Altgassen,Frank Noack,Monika M Wolfler,Klaus Diedrich,Michael Friedrich,Robert N Taylor,Daniela Hornung,

The authors demonstrate expression of the vitamin D receptor (VDR) and its hydroxylases in the endometrium and ovaries of women with and without endometriosis and endometrial or ovarian cancer. Immunohistochemistry showed strong staining of the VDR in endometriosis and endometrial cancer, with the most intense staining in epithelial cells. The VDR mRNA was significantly increased in patients with endometrial and ovarian cancer compared to the control group. There was a significantly higher 1 alpha-hydroxylase expression in the endometrium of patients with endometriosis compared to healthy controls. The observed differences in VDR and 1 alpha -hydroxylase mRNA levels were maintained at the protein level. The authors found no differences in 25-OH vitamin D levels between the serum of patients with endometriosis (25.7 +/- 2.1 ng/mL, n = 46) and healthy controls (22.6 +/- 2.0 ng/mL, n = 33, P = .31). They hypothesize that vitamin D might influence the local activity of immune cells and cytokines thought to play important pathogenic roles in the development and maintenance of endometriosis.

Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1 alpha-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxylase in endometriosis and gynecologic cancers. Publishing Authors By Initials

A Agic,H Xu,C Altgassen,F Noack,MM Wolfler,K Diedrich,M Friedrich,RN Taylor,D Hornung,A Agic,H Xu,C Altgassen,F Noack,MM Wolfler,K Diedrich,M Friedrich,RN Taylor,D Hornung,A Agic,H Xu,C Altgassen,F Noack,MM Wolfler,K Diedrich,M Friedrich,RN Taylor,D Hornung,

For similar enzymes and coenzymes: cytochromes: cytochrome p-450 enzyme system: steroid hydroxylases research abstracts see: enzymes and coenzymes: cytochromes: cytochrome p-450 enzyme system: steroid hydroxylases research

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Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1 alpha-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxylase in endometriosis and gynecologic cancers. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Reproductive sciences (Thousand Oaks, Calif.)

VOLUME: 14

Page Numbers: 486-97

Journal Abbreviation:

ISSN: 1933-7205

DAY: 31

MONTH: Jul

YEAR: 2007

Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1 alpha-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxylase in endometriosis and gynecologic cancers. Information

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LANGUAGE: eng

NlmUniqueID: 101291249

Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1 alpha-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxylase in endometriosis and gynecologic cancers. Keywords Mesh Terms:

KEYWORDS: Steroid Hydroxylases

MESH TERMS: genetics

Chemical & Substance for Abstract: Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1 alpha-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxylase in endometriosis and gynecologic cancers. Information

Substance Name: vitamin D 24-hydroxylase

Registry Number: EC 1.14.-

Grant and Affiliation Information for Relative expression of 1,25-dihydroxyvitamin D3 receptor, vitamin D 1 alpha-hydroxylase, vitamin D 24-hydroxylase, and vitamin D 25-hydroxylase in endometriosis and gynecologic cancers.

AFFILIATION: Department of Gynecology and Obstetrics, University of Schleswig-Holstein, Lübeck, Germany.

Country: United States

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MEDLINETA: Reprod Sci

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