Relative contributions of rod and cone bipolar cell inputs to AII amacrine cell light responses in the mouse retina.

Relative contributions of rod and cone bipolar cell inputs to AII amacrine cell light responses in the mouse retina. Research Abstract Details 

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Relative contributions of rod and cone bipolar cell inputs to AII amacrine cell light responses in the mouse retina. Abstract Text:

Ji-Jie Pang,Muhammad M Abd-El-Barr,Fan Gao,Debra E Bramblett,David L Paul,Samuel M Wu,

AII amacrine cells (AIIACs) are crucial relay stations for rod-mediated signals in the mammalian retina and they receive synaptic inputs from depolarizing and hyperpolarizing bipolar cells (DBCs and HBCs) as well as from other amacrine cells. Using whole-cell voltage-clamp technique in conjunction with pharmacological tools, we found that the light-evoked current response of AIIACs in the mouse retina is almost completely mediated by two DBC synaptic inputs: a 6,7-dinitro-quinoxaline-2,3-dione (DNQX)-resistant component mediated by cone DBCs (DBC(C)s) through an electrical synapse, and a DNQX-sensitive component mediated by rod DBCs (DBC(R)s). This scheme is supported by AIIAC current responses recorded from two knockout mice. The dynamic range of the AIIAC light response in the Bhlhb4-/- mouse (which lacks DBC(R)s) resembles that of the DNQX-resistant component, and that of the connexin36 (Cx36)-/- mouse resembles the DNQX-sensitive component. By comparing the light responses of the DBC(C)s with the DNQX-resistant AIIAC component, and light responses of the DBC(R)s with the DNQX-sensitive AIIAC component, we obtained the input-output relations of the DBC(C)-->AIIAC electrical synapse and the DBC(R)-->AIIAC chemical synapse. Similar to other glutamatergic chemical synapses in the retina, the DBC(R)-->AIIAC synapse is non-linear. Its highest voltage gain (approximately 5) is found near the dark membrane potential, and it saturates for presynaptic signals larger than 5.5 mV. The DBC(C)-->AIIAC electrical synapse is approximately linear (voltage gain of 0.92), consistent with the linear junctional conductance found in retinal electrical synapses. Moreover, relative DBC(R) and DBC(C) contributions to the AIIAC response at various light intensity levels are determined.

Relative contributions of rod and cone bipolar cell inputs to AII amacrine cell light responses in the mouse retina. Publishing Authors By Initials

JJ Pang,MM Abd-El-Barr,F Gao,DE Bramblett,DL Paul,SM Wu,

For similar nervous system: synapses research abstracts see: nervous system: synapses research

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Relative contributions of rod and cone bipolar cell inputs to AII amacrine cell light responses in the mouse retina. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of physiology

VOLUME: 580

Page Numbers: 397-410

Journal Abbreviation:

ISSN: 0022-3751

DAY: 25

MONTH: 01

YEAR: 2007

Relative contributions of rod and cone bipolar cell inputs to AII amacrine cell light responses in the mouse retina. Information

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LANGUAGE: eng

NlmUniqueID: 266262

Relative contributions of rod and cone bipolar cell inputs to AII amacrine cell light responses in the mouse retina. Keywords Mesh Terms:

KEYWORDS: Synapses

MESH TERMS: metabolism

Chemical & Substance for Abstract: Relative contributions of rod and cone bipolar cell inputs to AII amacrine cell light responses in the mouse retina. Information

Substance Name: FG 9041

Registry Number: 2379-57-9

Grant and Affiliation Information for Relative contributions of rod and cone bipolar cell inputs to AII amacrine cell light responses in the mouse retina.

AFFILIATION: Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA.

Country: England

AGENCY: United States NEI

GRANT: EY 04446

ACRONYM: EY

MEDLINETA: J Physiol

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