Relationship of thyroid stimulating hormone with coronary atherosclerosis in angina patients.

Relationship of thyroid stimulating hormone with coronary atherosclerosis in angina patients. Research Abstract Details 

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Relationship of thyroid stimulating hormone with coronary atherosclerosis in angina patients. Abstract Text:

Kyeong Ho Yun,Myung Ho Jeong,Seok Kyu Oh,Eun Mi Lee,Je Lee,Sang Jae Rhee,Nam Jin Yoo,Nam-Ho Kim,Young Keun Ahn,Jin-Won Jeong,Kyeong Ho Yun,Myung Ho Jeong,Seok Kyu Oh,Eun Mi Lee,Je Lee,Sang Jae Rhee,Nam Jin Yoo,Nam-Ho Kim,Young Keun Ahn,Jin-Won Jeong,Kyeong Ho Yun,Myung Ho Jeong,Seok Kyu Oh,Eun Mi Lee,Je Lee,Sang Jae Rhee,Nam Jin Yoo,Nam-Ho Kim,Young Keun Ahn,Jin-Won Jeong,

BACKGROUND: In the previous recent reports, subclinical hypothyroidism is an independent risk factor for acute myocardial infarction in elderly women. It was not established whether a normal range of thyroid stimulating hormone (TSH) influences the presence of coronary atherosclerosis. We postulated that the level of TSH is risk factor of coronary atherosclerosis in angina patients who have normal thyroid function. METHODS: We studied 344 angina patients (62.5+/-9.72 years, male 50%) who underwent elective coronary angiography. TSH, free thyroxine, serum lipid levels and high-sensitivity C-reactive protein levels were measured and compared to the severity of coronary artery disease. RESULTS: In patients with high level of TSH (> or =2.1 microIU/mL), age (p=0.016), the levels of serum creatinine (p=0.004) and Gensini's score (p=0.016) were significantly higher than those in patients with low TSH levels. The incidence of multi-vessel disease was higher in patients with high TSH level (p=0.026). TSH level showed a significant correlation with age (r=0.109, p=0.044) and Gensini's score (r=0.117, p=0.045). The multivariate analysis revealed that age (OR 2.39, p=0.001), diabetes (OR 3.74, p=0.001), creatinine (OR 2.06, p=0.008), and smoking (OR 1.85, p=0.045) were independent predictors for significant coronary artery disease, but TSH level did not predict coronary artery stenosis. CONCLUSIONS: Although the high level of serum TSH is associated with multi-vessel disease, it was not the determinant of coronary artery disease in patients with normal range of thyroid function.

Relationship of thyroid stimulating hormone with coronary atherosclerosis in angina patients. Publishing Authors By Initials

KH Yun,MH Jeong,SK Oh,EM Lee,J Lee,SJ Rhee,NJ Yoo,NH Kim,YK Ahn,JW Jeong,KH Yun,MH Jeong,SK Oh,EM Lee,J Lee,SJ Rhee,NJ Yoo,NH Kim,YK Ahn,JW Jeong,KH Yun,MH Jeong,SK Oh,EM Lee,J Lee,SJ Rhee,NJ Yoo,NH Kim,YK Ahn,JW Jeong,

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Relationship of thyroid stimulating hormone with coronary atherosclerosis in angina patients. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of cardiology

VOLUME: 122

Page Numbers: 56-60

Journal Abbreviation: Int. J. Cardiol.

ISSN: 1874-1754

DAY: 12

MONTH: 01

YEAR: 2007

Relationship of thyroid stimulating hormone with coronary atherosclerosis in angina patients. Information

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LANGUAGE: eng

NlmUniqueID: 8200291

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AFFILIATION: Department of Cardiovascular Medicine, Wonkwang University Hospital, Iksan, South Korea.

Country: Netherlands

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MEDLINETA: Int J Cardiol

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