Relationship of the lipopolysaccharide structure of Yersinia pestis to resistance to antimicrobial factors.

Relationship of the lipopolysaccharide structure of Yersinia pestis to resistance to antimicrobial factors. Research Abstract Details 

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Relationship of the lipopolysaccharide structure of Yersinia pestis to resistance to antimicrobial factors. Abstract Text:

Yuriy A Knirel,Svetlana V Dentovskaya,Olga V Bystrova,Nina A Kocharova,Sof'ya N Senchenkova,Rima Z Shaikhutdinova,Galina M Titareva,Irina V Bakhteeva,Buko Lindner,Gerald B Pier,Andrey P Anisimov,Yuriy A Knirel,Svetlana V Dentovskaya,Olga V Bystrova,Nina A Kocharova,Sof'ya N Senchenkova,Rima Z Shaikhutdinova,Galina M Titareva,Irina V Bakhteeva,Buko Lindner,Gerald B Pier,Andrey P Anisimov,

Disruption of lipopolysaccharide (LPS) biosynthesis genes in an epidemiologically significant Yersinia pestis strain showed that the ability to synthesize the full inner core of the LPS is crucial for resistances to the bactericidal action of antimicrobial peptides and to complement-mediated serum killing. Resistance to polymyxin B also requires a high content of the cationic sugar, 4-amino-4-deoxy-L-arabinose, in lipid A.

Relationship of the lipopolysaccharide structure of Yersinia pestis to resistance to antimicrobial factors. Publishing Authors By Initials

YA Knirel,SV Dentovskaya,OV Bystrova,NA Kocharova,SN Senchenkova,RZ Shaikhutdinova,GM Titareva,IV Bakhteeva,B Lindner,GB Pier,AP Anisimov,YA Knirel,SV Dentovskaya,OV Bystrova,NA Kocharova,SN Senchenkova,RZ Shaikhutdinova,GM Titareva,IV Bakhteeva,B Lindner,GB Pier,AP Anisimov,

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Relationship of the lipopolysaccharide structure of Yersinia pestis to resistance to antimicrobial factors. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Advances in experimental medicine and biology

VOLUME: 603

Page Numbers: 88-96

Journal Abbreviation: Adv. Exp. Med. Biol.

ISSN: 0065-2598

DAY: 26

MONTH: 10

YEAR: 2007

Relationship of the lipopolysaccharide structure of Yersinia pestis to resistance to antimicrobial factors. Information

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LANGUAGE: eng

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AFFILIATION: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia. knirel@ioc.ac.ru

Country: United States

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MEDLINETA: Adv Exp Med Biol

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