Relationship of sialic acid and fatty acid composition of brain gangliosides: breast-fed vs formula-fed infant.

Relationship of sialic acid and fatty acid composition of brain gangliosides: breast-fed vs formula-fed infant. Research Abstract Details 

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Relationship of sialic acid and fatty acid composition of brain gangliosides: breast-fed vs formula-fed infant. Abstract Text:

B Wang,P Petocz,J Brand Miller,

Background - Gangliosides are hybrid molecules composed of a hydrophilic sialyl oligosaccharide and a hydrophobic ceramide portion, which consists of sphingosine and fatty acids (FA). In animal studies, sialic acid (SA) supplementation is associated with increases in brain gangliosides and learning ability. Supplementation of docosahexanenoic acid (DHA) and archidonic acid (AA) in formula milk improved visual activity and psychomotor performance in premature infants. Objective - To investigate the association of feeding method with the levels of SA and FA, particularly DHA in the brain gangliosides. Design - Samples of frontal cortex from 12 infants who had been breast-fed and 10 who had been formula-fed (age of death 1 - 38 wks) were collected as part of a previous study on infants dying of sudden infant death. From 1g samples, gangliosides were extracted and purified. SA and FA levels were determined using HPLC and GLC respectively according to published methods. Outcomes - Significant correlation of gangliosides SA and LCPUFAs was found in breast-fed, but not formula-fed infants. Conclusions - Sialic acid and LCPUFAs are interdependent building blocks for gangliosides in neural tissues involved in higher cognitive function of human-fed infant than formula-fed.

Relationship of sialic acid and fatty acid composition of brain gangliosides: breast-fed vs formula-fed infant. Publishing Authors By Initials

B Wang,P Petocz,JB Miller,

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Relationship of sialic acid and fatty acid composition of brain gangliosides: breast-fed vs formula-fed infant. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Asia Pacific journal of clinical nutrition

VOLUME: 12 Suppl

Page Numbers: S43

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ISSN: 0964-7058

DAY: 16

MONTH: 03

YEAR: 2003

Relationship of sialic acid and fatty acid composition of brain gangliosides: breast-fed vs formula-fed infant. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Relationship of sialic acid and fatty acid composition of brain gangliosides: breast-fed vs formula-fed infant.

AFFILIATION: Human Nutrition Unit, School of Molecular and Microbial Biosciences,G08 University of Sydney, NSW 2006.

Country: Australia

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MEDLINETA: Asia Pac J Clin Nutr

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