Relationship of plasma adiponectin with sex hormone and insulin-like growth factor levels.

Relationship of plasma adiponectin with sex hormone and insulin-like growth factor levels. Research Abstract Details 

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Relationship of plasma adiponectin with sex hormone and insulin-like growth factor levels. Abstract Text:

Shelley S Tworoger,Christos Mantzoros,Susan E Hankinson,Shelley S Tworoger,Christos Mantzoros,Susan E Hankinson,Shelley S Tworoger,Christos Mantzoros,Susan E Hankinson,

OBJECTIVE: Recent studies have suggested that a relationship between adiponectin and sex hormone, prolactin, and insulin-like growth factor levels could be important for breast cancer risk and insulin sensitivity. Therefore, we assessed the relationship of adiponectin with plasma concentrations of estrone; estradiol; estrone sulfate; testosterone; androstenedione; dehydroepiandrosterone (DHEA); dehydroepiandrosterone sulfate (DHEAS); sex hormone binding globulin (SHBG); prolactin; insulin-like growth factor (IGF-1); its binding protein, IGF binding protein 3 (IGFBP-3); c-peptide; and IGF binding protein 1 (IGFBP-1) among 360 postmenopausal women not taking postmenopausal hormones from the Nurses' Health Study. RESEARCH METHODS AND PROCEDURES: Multivariate models were adjusted for physical activity, alcohol consumption, age at blood draw, age at first birth/parity, fasting status, and time of day of blood draw; a separate model was additionally adjusted for BMI at blood draw. RESULTS: Estrogens were inversely associated with adiponectin levels; however, except for free estradiol, these associations were substantially attenuated after adjustment for BMI. Free estradiol levels were 27% lower among women in the top vs. bottom quartile of adiponectin levels. No consistent associations were observed for the androgens, prolactin, IGF-1, and IGFBP-3. However, SHBG, c-peptide, and IGFBP-1 were strongly and independently associated with adiponectin levels (r = 0.29, -0.30, 0.24, respectively). Conclusion: With the exceptions of SHBG, c-peptide, and IGFBP-1, the studied analytes were modestly associated with adiponectin and the associations were, in large part, mediated by body fat.

Relationship of plasma adiponectin with sex hormone and insulin-like growth factor levels. Publishing Authors By Initials

SS Tworoger,C Mantzoros,SE Hankinson,SS Tworoger,C Mantzoros,SE Hankinson,SS Tworoger,C Mantzoros,SE Hankinson,

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Relationship of plasma adiponectin with sex hormone and insulin-like growth factor levels. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Obesity (Silver Spring, Md.)

VOLUME: 15

Page Numbers: 2217-24

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ISSN: 1930-7381

DAY: 24

MONTH: Sep

YEAR: 2007

Relationship of plasma adiponectin with sex hormone and insulin-like growth factor levels. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Relationship of plasma adiponectin with sex hormone and insulin-like growth factor levels.

AFFILIATION: Channing Laboratory, 181 Longwood Ave., 3rd Floor, Boston, MA 02115, USA. nhsst@channing.harvard.edu

Country: United States

AGENCY: United States NCI

GRANT: P01 CA87969

ACRONYM: CA

MEDLINETA: Obesity (Silver Spring)

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