Relationship of 5-HTTLPR genotypes and depression risk in the presence of trauma in a female twin sample.

Relationship of 5-HTTLPR genotypes and depression risk in the presence of trauma in a female twin sample. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Relationship of 5-HTTLPR genotypes and depression risk in the presence of trauma in a female twin sample. Abstract Text:

Vesselin M Chorbov,Elizabeth A Lobos,Alexandre A Todorov,Andrew C Heath,Kelly N Botteron,Richard D Todd,

Several studies have implicated an insertion/deletion polymorphism in the promoter region of the serotonin transporter gene (SLC6A4; 5-HTT) in the development of mood disorders. In the present study of a sample of 247 young adult female twins from Missouri, we examine whether this polymorphism interacts with the effect of adverse life events to increase risk for developing depression. We found a significant interaction between the number of high-activity L(A) alleles and exposure to trauma (OR = 1.70, P < 0.0001). This differs from previous reports, in that the higher activity genotypes (L(A)/L(A), L(A)/S, L(A)/L(G)), rather than the low activity genotypes (S/S, S/L(G), L(G)/L(G)), are associated with an increased incidence of major depressive disease (MDD) in the presence of environmental trauma.

Relationship of 5-HTTLPR genotypes and depression risk in the presence of trauma in a female twin sample. Publishing Authors By Initials

VM Chorbov,EA Lobos,AA Todorov,AC Heath,KN Botteron,RD Todd,

For similar disorders of environmental origin: wounds and injuries research abstracts see: disorders of environmental origin: wounds and injuries research

PUBMED ID PMID:

MEDLINE DATE:

Relationship of 5-HTTLPR genotypes and depression risk in the presence of trauma in a female twin sample. Journal Published:

PUBLICATION TYPE: Twin Study

Journal: American journal of medical genetics. Part B, Neur

VOLUME: 144

Page Numbers: 830-3

Journal Abbreviation: Am. J. Med. Genet. B Neuropsyc

ISSN: 1552-4841

DAY: 5

MONTH: Sep

YEAR: 2007

Relationship of 5-HTTLPR genotypes and depression risk in the presence of trauma in a female twin sample. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101235742

Relationship of 5-HTTLPR genotypes and depression risk in the presence of trauma in a female twin sample. Keywords Mesh Terms:

KEYWORDS: Wounds and Injuries

MESH TERMS: complications

Chemical & Substance for Abstract: Relationship of 5-HTTLPR genotypes and depression risk in the presence of trauma in a female twin sample. Information

Substance Name: Serotonin Plasma Membrane Transport Prot

Registry Number: 0

Grant and Affiliation Information for Relationship of 5-HTTLPR genotypes and depression risk in the presence of trauma in a female twin sample.

AFFILIATION: Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri 63110, USA.

Country: United States

AGENCY: United States NIMH

GRANT: MH62626

ACRONYM: MH

MEDLINETA: Am J Med Genet B Neuropsychiat

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Relationship of 5-HTTLPR genotypes and depression risk in the presence of trauma in a female twin sample Related Publications

• A population of large neurons in laminae III and IV of the rat spinal cord that have long dorsal dendrites and lack the neurokinin 1 receptor.
• A study of deaths associated with anesthesia and surgery.
• ADHD medication use in a population-based sample of twins.
• Autistic traits in a population-based ADHD twin sample.
• Bioinformatics approaches to quadruplex sequence location.
• Calcitonin receptor-like receptor and receptor activity modifying protein 1 in the rat dorsal horn: localization in glutamatergic presynaptic terminals containing opioids and adrenergic alpha2C receptors.
• Challenges to global surveillance of disease patterns.
• Clinical surveillance of thrombotic microangiopathies in Scotland, 2003-2005.
• Come all ye scientists, busy and exhausted. O come ye, O come ye, out of the lab.
• Does the Child Behavior Checklist juvenile bipolar disorder phenotype identify bipolar disorder?
• Eerie coincidence.
• Experiments on the synthesis of purine nucleosides; s synthesis of guanosine.
• Fast and frugal food choices: Uncovering individual decision heuristics.
• Genetic influences on free and cued recall in long-term memory tasks.
• Improving prediction of outcome in "good grade" subarachnoid hemorrhage.
• Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes.
• Older women with operable breast cancer are less likely to have surgery.
• Open access and open source in chemistry.
• Parameterization of the nonlocal viscosity kernel for an atomic fluid.
• Pars flaccida retraction and mastoid size: relationship in clinically normal specimens.
• Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype.
• Prevention of Falls Network Europe: a thematic network aimed at introducing good practice in effective falls prevention across Europe. Four years on.
• Recovery of cognitive function after surgery for aneurysmal subarachnoid hemorrhage.
• Relationship of 5-HTTLPR genotypes and depression risk in the presence of trauma in a female twin sample.
• Reliability of a telephone-based Glasgow Outcome Scale assessment using a structured interview in a heterogenous population of patients and examiners.
• The Best Warm-up For Optimal Vertical Jump Performance In Collegiate Female Volleyball Athletes: 1438: Board #201 May 30 9:30 AM - 11:00 AM.
• The occurrence of phenolic substances in arthropods.
• The psychological costs of unsustainable housing commitments.
• Treatment of peritonitis with parenteral streptomycin and penicillin.
• Unconscious, stimulus-dependent priming and conscious, percept-dependent priming with chromatic stimuli.