Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging.

Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging. Abstract Text:

P Kochunov,P M Thompson,J L Lancaster,G Bartzokis,S Smith,T Coyle,D R Royall,A Laird,P T Fox,

White matter (WM) fractional anisotropy (FA) is thought to be related to WM integrity and decline in FA is often used as an index of decreasing WM health. However, the relationship of FA to other structural indices of cerebral health has not been well studied. We hypothesized that the decline in WM health will be associated with changes in several other indices of cerebral health. In this manuscript we studied the correlation between whole-brain/hemispheric/corpus callosum FA and gray matter (GM) thickness, sulcal span, and the volume of T2-hyperintense WM in a group of 31 healthy aging individuals (12 males/19 females) aged 57-82 years old. Individual subjects' FA measures were calculated from diffusion tracing imaging (DTI) data using tract-based spatial statistics--an approach specifically designed and validated for voxel-wise multi-subject FA analysis. Age-controlled correlation analysis showed that whole-brain average FA values were significantly and positively correlated with the subject's average GM thickness and negatively correlated with hyperintense WM volume. Intra-hemispheric correlations between FA and other measures of cerebral health had generally greater effect sizes than inter-hemispheric correction, with correlation between left FA and left GM thickness being the most significant (r=0.6, p<0.01). Regional analysis of FA values showed that late-myelinating fiber tracts of the genu of corpus callosum had higher association with other cerebral health indices. These data are consistent with the hypothesis that late-myelinating regions of the brain bear the brunt of age-related degenerative changes.

Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging. Publishing Authors By Initials

P Kochunov,PM Thompson,JL Lancaster,G Bartzokis,S Smith,T Coyle,DR Royall,A Laird,PT Fox,

For similar persons: age groups: adult: middle aged research abstracts see: persons: age groups: adult: middle aged research

PUBMED ID PMID:

MEDLINE DATE:

Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: NeuroImage

VOLUME: 35

Page Numbers: 478-87

Journal Abbreviation: Neuroimage

ISSN: 1053-8119

DAY: 23

MONTH: 12

YEAR: 2006

Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9215515

Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging. Keywords Mesh Terms:

KEYWORDS: Middle Aged

MESH TERMS: statistics & numerical data

Chemical & Substance for Abstract: Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging.

AFFILIATION: Research Imaging Center, University of Texas Health Science Center at San Antonio, Research Imaging Center, 7703 Floyd Curl Drive, San Antonio, TX 78284, USA. kochunov@uthscsa.edu

Country: United States

AGENCY: United States NCRR

GRANT: RR019771

ACRONYM: RR

MEDLINETA: Neuroimage

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging Related Publications

• Absolute linearity measurements on HgCdTe detectors in the infrared region.
• Cognitive functioning in excessive drinkers: evidence for dissociable impairments.
• Comparison of the mutagenic potential of 17 physical and chemical agents analyzed by the flow cytometry mutation assay.
• Computational Neuronal Oscillations using Morlet Wavelet Transform.
• Diastereoselective synthesis of methylenecyclopropanes from chiral cyclopropene derivatives.
• Enantioselective, facially selective carbomagnesation of cyclopropenes.
• Enterohepatic Helicobacter species isolated from the ileum, liver and colon of a baboon with pancreatic islet amyloidosis.
• Evaluation of protein fractionation systems used in formulating rations for dairy cattle.
• Hypoxia-inducible factor-1alpha expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer.
• Identification of Rv3230c as the NADPH oxidoreductase of a two-protein DesA3 acyl-CoA desaturase in Mycobacterium tuberculosis H37Rv.
• Interleukin-17 as a molecular target in immune-mediated arthritis: immunoregulatory properties of genetically modified murine dendritic cells that secrete interleukin-4.
• Issues in estimating the prevalence of fetal alcohol syndrome: examination of 2 counties in New York State.
• MR imaging volumetry of subcortical structures and cerebellar hemispheres in temporal lobe epilepsy.
• Outcomes from a group intervention for coping with HIV/AIDS and childhood sexual abuse: reductions in traumatic stress.
• Prolonged survival of porcine hepatocytes in cynomolgus monkeys.
• Rapid discrimination of Bacillus anthracis from other members of the B. cereus group by mass and sequence of "intact" small acid soluble proteins (SASPs) using mass spectrometry.
• Rapid onset of ulcerative typhlocolitis in B6.129P2-IL10tm1Cgn (IL-10-/-) mice infected with Helicobacter trogontum is associated with decreased colonization by altered Schaedler's flora.
• Regulatory T cell defects in rheumatoid arthritis.
• Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging.
• Retrospective motion correction protocol for high-resolution anatomical MRI.
• Rh-catalyzed intermolecular reactions of alkynes with alpha-diazoesters that possess beta-hydrogens: ligand-based control over divergent pathways.
• Simian immunodeficiency virus-induced CD4+ T cell deficits in cytokine secretion profile are dependent on monkey origin.
• Synthesis of cyclopropene alpha-amino acids via enantioselective desymmetrization.
• The role of infant soothability in the relation between infant negativity and maternal sensitivity.
• The sociobiologic integrative model (SBIM): enhancing the integration of sociobehavioral, environmental, and biomolecular knowledge in urban health and disparities research.
• The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study.
• Translation initiation in Saccharomyces cerevisiae mitochondria: functional interactions among mitochondrial ribosomal protein Rsm28p, initiation factor 2, methionyl-tRNA-formyltransferase and novel protein Rmd9p.
• Translational control of ceruloplasmin gene expression: beyond the IRE.
• Using the Price Equation to partition the effects of biodiversity loss on ecosystem function.
• Variation in caregiver perceptions of teamwork climate in labor and delivery units.