Relationship between the expression of telomerase and human papillomavirus infection in invasive uterine cervical carcinoma.

Relationship between the expression of telomerase and human papillomavirus infection in invasive uterine cervical carcinoma. Research Abstract Details 

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Relationship between the expression of telomerase and human papillomavirus infection in invasive uterine cervical carcinoma. Abstract Text:

Ni Sima,Liping Cai,Yuanfang Zhu,Wei Wang,Shixuan Wang,Ding Ma,

Telomerase activity was examined in invasive cervical carcinoma to assess whether it is activated during cervical malignant transformation and to look for its possible association with human papillomavirus (HPV) infection. Histologically confirmed invasive cervical carcinomas and benign cervices were assayed for telomerase activity by using a modified telomere repeat amplification protocol (TRAP). The same cases were subjected to polymerase chain reaction (PCR) detection of HPV by using consensus primers and type-specific (HPV types 16 and 18) primers. Telomerase activity was detected in 40 of 45 (88.9%) invasive cervical carcinomas and 2 (all chronic cervicitis) of 50 (4%) benign cervical lesions. HPV was detected in 36 (24 HPV-16 and 4 HPV-18 cases) of 45 (80%) invasive cervical carcinomas and 20 (11 HPV-16 and 1 HPV-18 cases) of 50 (40%) benign cervical changes. There was a significant correlation between the expression of telomerase with histological grade (omega=0.44, P<0.005), but no correlation was found between telomerase expression and HPV-18 (P>0.05). Although larger sample studies are needed, there seems to be a clear association between telomerase upregulation and HPV status, mainly HPV-16 infection.

Relationship between the expression of telomerase and human papillomavirus infection in invasive uterine cervical carcinoma. Publishing Authors By Initials

N Sima,L Cai,Y Zhu,W Wang,S Wang,D Ma,

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Relationship between the expression of telomerase and human papillomavirus infection in invasive uterine cervical carcinoma. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of Huazhong University of Science and Tech

VOLUME: 27

Page Numbers: 451-3

Journal Abbreviation: J. Huazhong Univ. Sci. Technol

ISSN: 1672-0733

DAY: 10

MONTH: Aug

YEAR: 2007

Relationship between the expression of telomerase and human papillomavirus infection in invasive uterine cervical carcinoma. Information

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LANGUAGE: eng

NlmUniqueID: 101169627

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AFFILIATION: Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. simani@163.com

Country: China

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MEDLINETA: J Huazhong Univ Sci Technolog

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