Relationship between single nucleotide polymorphism in TNF-alpha gene promoter region and inhibitory effects of triptolide on TNF-alpha production in peripheral blood mononuclear cells of healthy humans.

Relationship between single nucleotide polymorphism in TNF-alpha gene promoter region and inhibitory effects of triptolide on TNF-alpha production in peripheral blood mononuclear cells of healthy humans. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Relationship between single nucleotide polymorphism in TNF-alpha gene promoter region and inhibitory effects of triptolide on TNF-alpha production in peripheral blood mononuclear cells of healthy humans. Abstract Text:

Shenghao Tu,Hongbo Chen,Dongyun Sheng,Yonghong Hu,Peilin Liu,

The relationship between tumour necrosis factor-alpha (TNF-alpha) gene polymorphism and inhibitory effects of triptolide on TNF-alpha production from peripheral blood mononuclear cells (PBMC) of healthy humans was investigated. Genomic DNA from 41 healthy people was typed for TNF-alpha--308 polymorphism by allele-specific polymorphism chain reaction (AS-PCR). The TNF-alpha concentration in the supernatant was measured by ELISA. The results showed that the production of TNF-alpha from TNF-alpha--308 non-G/G genotype PBMC was higher than that from TNF-alpha--308 G/G genotype PBMC after stimulated by LPS. Triptolide could lower the production of TNF-alpha from G/ G genotype PBMC, but had no effect on the level of TNF-alpha from non-G/G genotype PBMC. It was concluded that TNF-alpha gene polymorphism was related to the TNF-alpha production from triptolide-inhibited PBMC culture in healthy humans.

Relationship between single nucleotide polymorphism in TNF-alpha gene promoter region and inhibitory effects of triptolide on TNF-alpha production in peripheral blood mononuclear cells of healthy humans. Publishing Authors By Initials

S Tu,H Chen,D Sheng,Y Hu,P Liu,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Relationship between single nucleotide polymorphism in TNF-alpha gene promoter region and inhibitory effects of triptolide on TNF-alpha production in peripheral blood mononuclear cells of healthy humans. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of Huazhong University of Science and Tech

VOLUME: 26

Page Numbers: 347-9

Journal Abbreviation:

ISSN: 1672-0733

DAY: 11

MONTH: 09

YEAR: 2006

Relationship between single nucleotide polymorphism in TNF-alpha gene promoter region and inhibitory effects of triptolide on TNF-alpha production in peripheral blood mononuclear cells of healthy humans. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101169627

Relationship between single nucleotide polymorphism in TNF-alpha gene promoter region and inhibitory effects of triptolide on TNF-alpha production in peripheral blood mononuclear cells of healthy humans. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Relationship between single nucleotide polymorphism in TNF-alpha gene promoter region and inhibitory effects of triptolide on TNF-alpha production in peripheral blood mononuclear cells of healthy humans. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Relationship between single nucleotide polymorphism in TNF-alpha gene promoter region and inhibitory effects of triptolide on TNF-alpha production in peripheral blood mononuclear cells of healthy humans.

AFFILIATION: Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Huazhong Univ Sci Technolog

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Relationship between single nucleotide polymorphism in TNF-alpha gene promoter region and inhibitory effects of triptolide on TNF-alpha production in peripheral blood mononuclear cells of healthy humans Related Publications

• Altered mucin gene expression in stone-containing intrahepatic bile ducts and cholangiocarcinomas.
• Clinical study on labor pain relief using the combined spinal-epidural analgesia and inhaling nitrous oxide.
• Detection of cariogenic Streptococcus mutans by quantitative polymerase chain reaction.
• Diagnosis and treatment of primary gastric non-Hodgkin's lymphoma: analysis of 157 patients.
• Experimental study on the effect of cyclosporine A drug delivery system implanted in anterior chamber on high-risk corneal graft rejection.
• Inhibitory effects of RRR-alpha-tocopheryl succinate on benzo(a)pyrene (B(a)P)-induced forestomach carcinogenesis in female mice.
• Mechanism and treatments of regression and haze after photorefractive keratectomy.
• Reconstruction and transplantation of composite skin containing keratinocytes and fibroblasts.
• Studies of WT1 gene expression in leukemia patients.
• [A case report of primary sclerosing cholangiolitis with Budd-Chiari syndrome]
• [A study on the epidemiological characteristics and the preventive measures of rabies in Shanghai]
• [Clinical and pathological characteristics of primary biliary cirrhosis]
• [Clinical results of transmyocardial laser revascularization for 77 patients with coronary artery disease]
• [Difference in action sites between mecamylamine and hexamethonium on nicotinic receptors of sympathetic neurons]
• [Differences of nitric oxide synthase expression and activity between splanchnic arterial and venous vessels of cirrhotic rats]
• [Effects of recombinant human bone morphogenic protein-2 and hyaluronic acid on invasion of brain glioma in vivo]
• [Improved three-dimension reconstruction of serial frozen tissue sections of the temporal bone of guinea pigs]
• [Measurement of anti-acetaldehyde protein adduct IgA, IgG, IgM antibody titers in the sera of human alcoholics]
• [Recent research advances in oxidized high density lipoproteins]
• [Regulation of c-myc expression in leukemic cell line Meg-01 by the death domain of Fas gene]
• [Relationship between the proliferative activity of cancer cells and microvessel density in portal vein thrombosis and transfer of hepatocellular carcinoma]
• [Studies on cell transformation and cell cycle in human embryo lungs induced by nickel compounds]
• [Study on the epidemiological feature and control measure for rabies from 1990 to 2000 in Jiangsu province]
• [Surgical treatment of epispadias]
• [The application of colour Doppler and ultrasonography the grading and staging of chronic hepatitis with and without liver cirrhosis]
• [The determination of anions of very weak acids by incompletely suppressed conductometric detection]
• [The experimental study on the activity of rhBMP-2, coral and collagen composites inducing intramuscle bone]
• [The expression of P16, P21(WAF1/CIP1) and Cyclin D1 proteins in skin of patients with arseniasis caused by coal-burning and their significance]
• [The sinus node itself also plays a role in heart rate slowing down during postnatal development]
• [The ultrastructure of bone morphogenetic protein 2 gene transfected human periodontal ligament fibroblasts]