Relationship between self-reported apathy and executive dysfunction in nondemented patients with Parkinson disease.

Relationship between self-reported apathy and executive dysfunction in nondemented patients with Parkinson disease. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Relationship between self-reported apathy and executive dysfunction in nondemented patients with Parkinson disease. Abstract Text:

Dennis J Zgaljardic,Joan C Borod,Nancy S Foldi,Mary Rocco,Paul J Mattis,Mark F Gordon,Andrew S Feigin,David Eidelberg,

OBJECTIVE: The prevalence of apathy was assessed across select cognitive and psychiatric variables in 32 nondemented patients with Parkinson disease (PD) and 29 demographically matched healthy control participants. BACKGROUND: Apathy is common in PD, although differentiating apathy from motor, cognitive, and/or other neuropsychiatric symptoms can be challenging. Previous studies have reported a positive relationship between apathy and cognitive impairment, particularly executive dysfunction. METHOD: Patients were categorized according to apathy symptom severity. Stringent criteria were used to exclude patients with dementia. RESULTS: Approximately 44% of patients endorsed significant levels of apathy. Those patients performed worse than patients with nonsignificant levels of apathy on select measures of verbal fluency and on a measure of verbal and nonverbal conceptualization. Further, they reported a greater number of symptoms related to depression and behavioral disturbance than did those patients with nonsignificant levels of apathy. Apathy was significantly related to self-report of depression and executive dysfunction. Performance on cognitive tasks assessing verbal fluency, working memory, and verbal abstraction and also on a self-report measure of executive dysfunction was shown to significantly predict increasing levels of apathy. CONCLUSIONS: Our findings suggest that apathy in nondemented patients with PD seems to be strongly associated with executive dysfunction.

Relationship between self-reported apathy and executive dysfunction in nondemented patients with Parkinson disease. Publishing Authors By Initials

DJ Zgaljardic,JC Borod,NS Foldi,M Rocco,PJ Mattis,MF Gordon,AS Feigin,D Eidelberg,

For similar investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research abstracts see: investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research

PUBMED ID PMID:

MEDLINE DATE:

Relationship between self-reported apathy and executive dysfunction in nondemented patients with Parkinson disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cognitive and behavioral neurology : official jour

VOLUME: 20

Page Numbers: 184-92

Journal Abbreviation:

ISSN: 1543-3633

DAY: 30

MONTH: Sep

YEAR: 2007

Relationship between self-reported apathy and executive dysfunction in nondemented patients with Parkinson disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101167278

Relationship between self-reported apathy and executive dysfunction in nondemented patients with Parkinson disease. Keywords Mesh Terms:

KEYWORDS: Severity of Illness Index

MESH TERMS: epidemiology

Chemical & Substance for Abstract: Relationship between self-reported apathy and executive dysfunction in nondemented patients with Parkinson disease. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Relationship between self-reported apathy and executive dysfunction in nondemented patients with Parkinson disease.

AFFILIATION: Transitional Learning Center at Galveston, Galveston, TX 77550, USA. dzgaljardic@tlc-galveston.org

Country: United States

AGENCY: United States NINDS

GRANT: R01 NS35069

ACRONYM: NS

MEDLINETA: Cogn Behav Neurol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Relationship between self-reported apathy and executive dysfunction in nondemented patients with Parkinson disease Related Publications

• Abnormal metabolic network activity in Parkinson's disease: test-retest reproducibility.
• Abnormal metabolic networks in atypical parkinsonism.
• An examination of executive dysfunction associated with frontostriatal circuitry in Parkinson's disease.
• Callosal and non-callosal connexions between the sensory-motor cortices in cat and monkey.
• Cerebral glucose metabolism and D(2)/D (3) receptor availability in young adults with cannabis dependence measured with positron emission tomography.
• Changes in network activity with the progression of Parkinson's disease.
• Correlates of movement initiation and velocity in Parkinson's disease: A longitudinal PET study.
• Development of electrical activity in the cerebral cortex of the newborn rat.
• Dissociation of metabolic and neurovascular responses to levodopa in the treatment of Parkinson's disease.
• Dopaminergic suppression of brain deactivation responses during sequence learning.
• Functional imaging of cerebral blood flow and glucose metabolism in Parkinson's disease and Huntington's disease.
• Functional imaging of sequence learning in Parkinson's disease.
• Gene transfer therapy for neurodegenerative disorders.
• Habituation of somatosensory evoked potentials in the lemniscal system of the cat.
• Implicit and explicit aspects of sequence learning in pre-symptomatic Huntington's disease.
• Increased cerebellar activation during sequence learning in DYT1 carriers: an equiperformance study.
• Metabolic abnormalities associated with mild cognitive impairment in Parkinson disease.
• Metabolic brain networks associated with cognitive function in Parkinson's disease.
• Metabolic correlates of subthalamic nucleus activity in Parkinson's disease.
• Microstructural white matter changes in primary torsion dystonia.
• Modulation of metabolic brain networks after subthalamic gene therapy for Parkinson's disease.
• Relationship between self-reported apathy and executive dysfunction in nondemented patients with Parkinson disease.
• Spectrum analysis of residual EEG changes following post-natal x-irradiation in rats.
• Subthalamic glutamic acid decarboxylase gene therapy: changes in motor function and cortical metabolism.
• Thalamic metabolism and symptom onset in preclinical Huntington's disease.
• The assessment of neurological systems with functional imaging.
• Thermoelectric freezing stage for serial brain sectioning.
• [Not Available.]
• [Not Available.]
• [Treatment of pain in neoplastic diseases.]