Relationship between psychiatric status and frontal-subcortical systems in HIV-infected individuals.

Relationship between psychiatric status and frontal-subcortical systems in HIV-infected individuals. Research Abstract Details 

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Relationship between psychiatric status and frontal-subcortical systems in HIV-infected individuals. Abstract Text:

Michael A Cole,Steven A Castellon,Adam C Perkins,Oscar S Ureno,Marta B Robinet,Matthew J Reinhard,Terry R Barclay,Charles H Hinkin,

Human immunodeficiency virus (HIV)-infected adults frequently evidence both neurocognitive and psychiatric dysfunction. It was hypothesized that apathy and irritability, but not anxiety and depression, are related to HIV effects on frontal-subcortical systems. This hypothesis was evaluated by determining the degree to which these psychiatric features are associated with neurocognitive functioning that is dependent upon frontal-subcortical circuitry and, therefore, thought to be sensitive to the central nervous system effects of HIV. Rating scales assessing irritability, apathy, depression, and anxiety and a dual-task paradigm were administered to 189 HIV-seropositive (HIV+) and 53 HIV-seronegative participants. Deficits in dual-task performance and greater anxiety, depression, apathy, and irritability were observed in HIV+ participants. Simultaneous multivariate regression and communality analyses revealed that only apathy and irritability were associated with dual-task performance in HIV+ participants. Thus, these findings suggest that apathy and irritability, but not depression and anxiety, are likely associated with the effects of HIV on frontal-subcortical circuitry.

Relationship between psychiatric status and frontal-subcortical systems in HIV-infected individuals. Publishing Authors By Initials

MA Cole,SA Castellon,AC Perkins,OS Ureno,MB Robinet,MJ Reinhard,TR Barclay,CH Hinkin,

For similar behavioral disciplines and activities: psychiatric status rating scales research abstracts see: behavioral disciplines and activities: psychiatric status rating scales research

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Relationship between psychiatric status and frontal-subcortical systems in HIV-infected individuals. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of the International Neuropsychological So

VOLUME: 13

Page Numbers: 549-54

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ISSN: 1355-6177

DAY: 3

MONTH: May

YEAR: 2007

Relationship between psychiatric status and frontal-subcortical systems in HIV-infected individuals. Information

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LANGUAGE: eng

NlmUniqueID: 9503760

Relationship between psychiatric status and frontal-subcortical systems in HIV-infected individuals. Keywords Mesh Terms:

KEYWORDS: Psychiatric Status Rating Scales

MESH TERMS: etiology

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Grant and Affiliation Information for Relationship between psychiatric status and frontal-subcortical systems in HIV-infected individuals.

AFFILIATION: Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA. micole@mednet.ucla.edu

Country: England

AGENCY: United States NIMH

GRANT: T32 MH019535

ACRONYM: MH

MEDLINETA: J Int Neuropsychol Soc

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