Relationship between periodontal infections and systemic disease.

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Relationship between periodontal infections and systemic disease. Abstract Text:

G J Seymour,P J Ford,M P Cullinan,S Leishman,K Yamazaki,

Oral conditions such as gingivitis and chronic periodontitis are found worldwide and are among the most prevalent microbial diseases of mankind. The cause of these common inflammatory conditions is the complex microbiota found as dental plaque, a complex microbial biofilm. Despite 3000 years of history demonstrating the influence of oral status on general health, it is only in recent decades that the association between periodontal diseases and systemic conditions such as coronary heart disease and stroke, and a higher risk of preterm low birth-weight babies, has been realised. Similarly, recognition of the threats posed by periodontal diseases to individuals with chronic diseases such as diabetes, respiratory diseases and osteoporosis is relatively recent. Despite these epidemiological associations, the mechanisms for the various relationships remain unknown. Nevertheless, a number of hypotheses have been postulated, including common susceptibility, systemic inflammation with increased circulating cytokines and mediators, direct infection and cross-reactivity or molecular mimicry between bacterial antigens and self-antigens. With respect to the latter, cross-reactive antibodies and T-cells between self heat-shock proteins (HSPs) and Porphyromonas gingivalis GroEL have been demonstrated in the peripheral blood of patients with atherosclerosis as well as in the atherosclerotic plaques themselves. In addition, P. gingivalis infection has been shown to enhance the development and progression of atherosclerosis in apoE-deficient mice. From these data, it is clear that oral infection may represent a significant risk-factor for systemic diseases, and hence the control of oral disease is essential in the prevention and management of these systemic conditions.

Relationship between periodontal infections and systemic disease. Publishing Authors By Initials

GJ Seymour,PJ Ford,MP Cullinan,S Leishman,K Yamazaki,

For similar bacteria: bacteroidetes: bacteroidaceae: porphyromonas: porphyromonas gingivalis research abstracts see: bacteria: bacteroidetes: bacteroidaceae: porphyromonas: porphyromonas gingivalis research

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Relationship between periodontal infections and systemic disease. Journal Published:

PUBLICATION TYPE: Review

Journal: Clinical microbiology and infection : the official

VOLUME: 13 Suppl 4

Page Numbers: 3-10

Journal Abbreviation: Clin. Microbiol. Infect.

ISSN: 1198-743X

DAY: 20

MONTH: Oct

YEAR: 2007

Relationship between periodontal infections and systemic disease. Information

Number of References: 51

LANGUAGE: eng

NlmUniqueID: 9516420

Relationship between periodontal infections and systemic disease. Keywords Mesh Terms:

KEYWORDS: Porphyromonas gingivalis

MESH TERMS: microbiology

Chemical & Substance for Abstract: Relationship between periodontal infections and systemic disease. Information

Substance Name: C-Reactive Protein

Registry Number: 9007-41-4

Grant and Affiliation Information for Relationship between periodontal infections and systemic disease.

AFFILIATION: Faculty of Dentistry, University of Otago, Dunedin, New Zealand. gregory.seymour@dent.otago.ac.nz

Country: France

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MEDLINETA: Clin Microbiol Infect

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