[Relationship between myocyte proliferation and cardiac function in adult rats with heart failure]

[Relationship between myocyte proliferation and cardiac function in adult rats with heart failure] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Relationship between myocyte proliferation and cardiac function in adult rats with heart failure] Abstract Text:

Hao Li,Jian-guo He,Qing-hua Liu,Da-jun Deng,Zhen-jun Wu,Wen-yuan Guo,Jing-feng Ding,Xian-sheng Cheng,

OBJECTIVE: To confirm whether there is myocytes proliferation in the adult rat with heart failure or not, and to investigate the relationship between myocyte proliferation and heart function. METHODS: Descending anterior branch of left coronary artery was ligated in 20 adult male SD rats so as to establish an heart failure models. Eight rats were used as controls. Hemodynamic parameters, blood pressure (BP), left ventricle end systolic pressure (LVESP), left ventricle end diastolic pressure (LVEDP), +LVdp/dt(max), and -LVdp/dt(max), were measured 30 days after the coronary occlusion. Based on the results of heart function examination, the heart infarct rats were divided into 2 subgroups: cardiac functional compensation subgroup (8 rats), and cardiac functional decompensation subgroup (6 rats). Then the rats were killed and their hearts were taken out and stained with propidium iodide (PI) and antibody to alpha-sarcomeric actin. Immunohistochemistry was used to detect the proliferation cell nuclear antigen (PCNA). Confocal microscopy was used to observe the mitotic image. Light microscopy was used to observe the PCNA positive rate in the myocardium. RESULTS: (1) Mitotic images of myocytes could be identified by confocal microscopy in the left ventricle of all rats. (2) PCNA expression was detected in the nuclei of both infarct and normal hearts. The PCNA positive rate of the cardiac functional compensation subgroup was 7.2% +/- 1.4%, significantly higher than that of the control group (2.2% +/- 0.8%, P = 0.648). However, the PCNA positive rate of the cardiac functional decompensation subgroup was 3.0% +/- 1.3%, not significantly different from that of the control group (P = 0.648). (3) The correlation coefficient between PCNA-positivity of cardiomyocytes and +LVdp/dt(max) in the infarct rats were 0.80 (P < 0.01) and the correlation coefficient between PCNA-positivity of cardiomyocytes and -LVdp/dt(max) was -0.76 (P = 0.01). CONCLUSION: (1) There is myocyte proliferation in the adult rat heart. (2) Myocyte proliferation is positively correlated with heart systolic function, and negatively correlated with heart diastolic function in chronic heart failure.

[Relationship between myocyte proliferation and cardiac function in adult rats with heart failure] Publishing Authors By Initials

H Li,JG He,QH Liu,DJ Deng,ZJ Wu,WY Guo,JF Ding,XS Cheng,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

[Relationship between myocyte proliferation and cardiac function in adult rats with heart failure] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua yi xue za zhi

VOLUME: 86

Page Numbers: 102-5

Journal Abbreviation: Zhonghua Yi Xue Za Zhi

ISSN: 0376-2491

DAY: 10

MONTH: Jan

YEAR: 2006

[Relationship between myocyte proliferation and cardiac function in adult rats with heart failure] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 7511141

[Relationship between myocyte proliferation and cardiac function in adult rats with heart failure] Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: [Relationship between myocyte proliferation and cardiac function in adult rats with heart failure] Information

Substance Name:

Registry Number:

Grant and Affiliation Information for [Relationship between myocyte proliferation and cardiac function in adult rats with heart failure]

AFFILIATION: Center of Diagnosis and Treatment for Pulmonary Vascular Diseases, Institute of Cardiovascular Diseases, Fuwai Cardiology Hospital, Peking Medical University, Beijing 100037, China.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Zhonghua Yi Xue Za Zhi

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Relationship between myocyte proliferation and cardiac function in adult rats with heart failure Related Publications

• Alphavbeta integrins play an essential role in BMP-2 induction of osteoblast differentiation.
• Ethnic differences in incidence of diseases and response to medicines.
• Neurological improvement after cranioplasty - analysis by transcranial doppler ultrasonography.
• Parallel approach for solution-phase synthesis of 2-quinoxalinol analogues and their inhibition of LPS-induced TNF-alpha release on mouse macrophages in vitro.
• Regulation of bone matrix protein expression and induction of differentiation of human osteoblasts and human bone marrow stromal cells by bone morphogenetic protein-2.
• Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor-beta in normal human osteoblastic cells.
• [A new approach to the fast measurement of content of amino acids in Cordyceps sinensis by ANN-NIR]
• [A strain of A/PR/8/34 (H1N1)-like virus isolated from men]
• [An overview of injectable and absorbable gelling scaffolds]
• [Analysis of single cells by capillary electrophoresis]
• [Application of biodegradable polyhydroxybutyrate in medicine and tissue engineering]
• [Bioartificial liver support system: state of the art]
• [Changes in voltage-dependent calcium channel currents of vascular smooth muscle cells isolated from small mesenteric arteries of simulated weightless rats.]
• [Determination of docosyl ferulate in extract of Pygeum africanton Hook. by high performance liquid chromatography (HPLC)]
• [Determination of mercury and selenium in bone by atomic absorption spectrometry after microwave digestion]
• [Determination of potassium, calcium, manganese, chromium and cadmium in 10 kinds of (tobacco) cigarettes by flame atomic absorption spectrophotometer]
• [Experience of ZHANG Jian-Qiu in treating "extraordinary meridian diseases" based on syndrome differentiation of miscellaneous diseases]
• [Experimental study on the myogenic differentiation of marrow mesenchymal stem cells in the local muscle tissues]
• [Expression, localization and interrelationship of P27kip1 and cyclin D3 in non-Hodgkin's lymphoma]
• [Pursue one's study and cultivate one's morality in scientific research]
• [Relation between activation of NF-kappa B and chemotherapy induced apoptosis of leukemic cells]
• [Relationship between myocyte proliferation and cardiac function in adult rats with heart failure]
• [Scatter correction of PET based on non-linear statistical estimate method]
• [Species composition and ecological distribution of planktonic diatoms in the Changjiang River estuary during spring]
• [Study on the cloning goat by cross-breed somatic cell nuclear transfer]
• [Study on the interaction of metal ion in active center of superoxide dismutase with cobalt chloride by visible spectroscopy]
• [Study on the relationship between Fas expression and apoptosis in oral squamous cell carcinoma]
• [The effects of interleukin-11 on high-dose methotrexate (HDMTX) induced mucositis in Wistar rats.]
• [The protective effect of basic fibroblast growth factor (bFGF) and electroacupuncture on neurons against cerebral ischemia]
• [The role of homeobox B2 gene in vascular endothelial proliferation and the protective effects of VEGF on the endothelia against radiation injury]