Relationship between MUC5AC and altered expression of MLH1 protein in mucinous and non-mucinous colorectal carcinomas.

Relationship between MUC5AC and altered expression of MLH1 protein in mucinous and non-mucinous colorectal carcinomas. Research Abstract Details 

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Relationship between MUC5AC and altered expression of MLH1 protein in mucinous and non-mucinous colorectal carcinomas. Abstract Text:

Lorena Losi,Alessandra Scarselli,Piero Benatti,Maurizio Ponz de Leon,Luca Roncucci,Monica Pedroni,Francesca Borghi,Igor Lamberti,Giuseppina Rossi,Massimiliano Marino,Giovanni Ponti,Giovanni Zangardi,Mirco Menigatti,Carmela Di Gregorio,

The main purpose of this study was to examine the expression of mucins and mismatch repair proteins in colorectal carcinomas. The immunohistochemical distribution of apomucins MUC2, MUC5AC, and the expression of MLH1 and MSH2 proteins were examined in 76 mucinous and 60 non-mucinous colorectal carcinomas. MUC2 was noted in all mucinous carcinomas, whereas MUC5AC was present in 41 cases only (54%). In non-mucinous carcinomas, MUC2 was expressed in 61.7% of the tumors; by contrast, MUC5AC was present in 20% of the cases. The expression level of apomucins was significantly different in mucinous and non-mucinous lesions (p<0.001). Twenty-seven (35.5%) of the mucinous carcinomas showed no MLH1 expression, whereas 11 (18.3%) of the non-mucinous tumors did. This difference was statistically significant (p<0.005). Altered expression of MSH2 protein was never observed. The lack of MLH1 expression was considerably more frequent in carcinomas with secretion of MUC5AC (p<0.005). Our study has demonstrated this close relationship by immunohistochemical methods. In summary, our data show: (1) differences in the expression of mucins between mucinous and non-mucinous tumors; (2) a high frequency of altered MLH1 protein expression (35.5%) in mucinous carcinomas; (3) a significant relationship between the presence of MUC5AC and the altered expression of MLH1 protein in colorectal carcinomas.

Relationship between MUC5AC and altered expression of MLH1 protein in mucinous and non-mucinous colorectal carcinomas. Publishing Authors By Initials

L Losi,A Scarselli,P Benatti,M Ponz de Leon,L Roncucci,M Pedroni,F Borghi,I Lamberti,G Rossi,M Marino,G Ponti,G Zangardi,M Menigatti,C Di Gregorio,

For similar proteins: nuclear proteins research abstracts see: proteins: nuclear proteins research

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Relationship between MUC5AC and altered expression of MLH1 protein in mucinous and non-mucinous colorectal carcinomas. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pathology, research and practice

VOLUME: 200

Page Numbers: 371-7

Journal Abbreviation: Pathol. Res. Pract.

ISSN: 0344-0338

DAY: 30

MONTH: 11

YEAR: 2004

Relationship between MUC5AC and altered expression of MLH1 protein in mucinous and non-mucinous colorectal carcinomas. Information

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LANGUAGE: eng

NlmUniqueID: 7806109

Relationship between MUC5AC and altered expression of MLH1 protein in mucinous and non-mucinous colorectal carcinomas. Keywords Mesh Terms:

KEYWORDS: Nuclear Proteins

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: Relationship between MUC5AC and altered expression of MLH1 protein in mucinous and non-mucinous colorectal carcinomas. Information

Substance Name: mucin 5AC

Registry Number: 0

Grant and Affiliation Information for Relationship between MUC5AC and altered expression of MLH1 protein in mucinous and non-mucinous colorectal carcinomas.

AFFILIATION: Department of Pathology, University of Modena and Reggio Emilia, Italy. losi.lo@policlinico.mo.it

Country: Germany

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MEDLINETA: Pathol Res Pract

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