Relationship between decreased expression of squamous cell carcinoma antigen 2 and E-cadherin in primary cervical cancer lesions and lymph node metastasis.

Relationship between decreased expression of squamous cell carcinoma antigen 2 and E-cadherin in primary cervical cancer lesions and lymph node metastasis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Relationship between decreased expression of squamous cell carcinoma antigen 2 and E-cadherin in primary cervical cancer lesions and lymph node metastasis. Abstract Text:

Akihiro Murakami,Tatsushi Nakagawa,Chikako Fukushima,Mayumi Torii,Kotaro Sueoka,Shugo Nawata,Osamu Takeda,Hitoshi Ishikawa,Norihiro Sugino,Akihiro Murakami,Tatsushi Nakagawa,Chikako Fukushima,Mayumi Torii,Kotaro Sueoka,Shugo Nawata,Osamu Takeda,Hitoshi Ishikawa,Norihiro Sugino,Akihiro Murakami,Tatsushi Nakagawa,Chikako Fukushima,Mayumi Torii,Kotaro Sueoka,Shugo Nawata,Osamu Takeda,Hitoshi Ishikawa,Norihiro Sugino,

Squamous cell carcinoma antigen (SCCA) has been used for the management of squamous cell carcinoma, especially in order to evaluate therapeutic effects and monitor recurrence. Recent studies have shown that SCCA performs several biological functions and can influence the behavior of cancer cells. It is well known that altered expression of E-cadherin is involved in the process of cancer invasion and metastasis. The present study was therefore undertaken to investigate the relationship between the expression of SCCA, E-cadherin and lymph node metastasis in advanced cervical squamous cell carcinoma patients. We studied 70 patients who had undergone radical hysterectomy and pelvic lymphadenectomy for stage IB, IIA and IIB of the disease, without pretreatments. Immunohistochemistry, using monoclonal antibodies against SCCA2 and E-cadherin, was performed to examine the relationship between SCCA2 and E-cadherin expression patterns in primary cancer lesions and lymph node metastasis. There was a significant positive relationship between the two expression patterns in primary cancer lesions (p<0.01). Both exhibited a heterogeneous expression pattern in the primary tumor which indicated a significant relationship with lymph node metastasis (p<0.01). Our data clearly show that SCCA2 expression is significantly related to E-cadherin expression and that the heterogeneous pattern of SCCA and E-cadherin in primary lesions is strongly associated with the high incidence of lymph node metastasis in cervical squamous cell carcinoma. These findings suggest that SCCA2 may be involved in cancer behavior such as metastasis, and as such can be a useful marker in predicting lymph node metastasis.

Relationship between decreased expression of squamous cell carcinoma antigen 2 and E-cadherin in primary cervical cancer lesions and lymph node metastasis. Publishing Authors By Initials

A Murakami,T Nakagawa,C Fukushima,M Torii,K Sueoka,S Nawata,O Takeda,H Ishikawa,N Sugino,A Murakami,T Nakagawa,C Fukushima,M Torii,K Sueoka,S Nawata,O Takeda,H Ishikawa,N Sugino,A Murakami,T Nakagawa,C Fukushima,M Torii,K Sueoka,S Nawata,O Takeda,H Ishikawa,N Sugino,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Relationship between decreased expression of squamous cell carcinoma antigen 2 and E-cadherin in primary cervical cancer lesions and lymph node metastasis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Oncology reports

VOLUME: 19

Page Numbers: 99-104

Journal Abbreviation: Oncol. Rep.

ISSN: 1021-335X

DAY: 21

MONTH: Jan

YEAR: 2008

Relationship between decreased expression of squamous cell carcinoma antigen 2 and E-cadherin in primary cervical cancer lesions and lymph node metastasis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9422756

Relationship between decreased expression of squamous cell carcinoma antigen 2 and E-cadherin in primary cervical cancer lesions and lymph node metastasis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Relationship between decreased expression of squamous cell carcinoma antigen 2 and E-cadherin in primary cervical cancer lesions and lymph node metastasis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Relationship between decreased expression of squamous cell carcinoma antigen 2 and E-cadherin in primary cervical cancer lesions and lymph node metastasis.

AFFILIATION: Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine, Ube 755-8505, Japan.

Country: Greece

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Oncol Rep

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Relationship between decreased expression of squamous cell carcinoma antigen 2 and E-cadherin in primary cervical cancer lesions and lymph node metastasis Related Publications

• Activin induces long-lasting N-methyl-d-aspartate receptor activation via scaffolding PDZ protein activin receptor interacting protein 1.
• Comparison of denaturation by guanidine hydrochloride of the wild type tryptophan synthase alpha-subunit of Escherichia coli and two mutant protein (Glu 49 replaced by Met or Gln).
• DNA helicase III of Saccharomyces cerevisiae, encoded by YER176w (HEL1), highly unwinds covalently closed, circular DNA in the presence of a DNA topoisomerase and yRF-A.
• Different changes in resistance index between uterine artery and uterine radial artery during early pregnancy.
• Effect of a single amino acid substitution on the near-ultraviolet CD spectra of tryptophan synthase alpha-subunit.
• Effects of growth hormone and insulin-like growth factor 1 on progesterone production in human luteinized granulosa cells.
• Fetal/placental regulation of maternal melatonin in rats.
• Fetoscopic laser photocoagulation of placental communicating vessels for twin-reversed arterial perfusion sequence.
• GINS is a DNA polymerase epsilon accessory factor during chromosomal DNA replication in budding yeast.
• GINS is a DNA polymerase epsilon accessory factor during chromosomal DNA replication in budding yeast.
• Identification and characterization of a novel follistatin-like protein as a binding protein for the TGF-beta family.
• In memory - Emeritus Professor Kenzo Oshima.
• Lyonization pattern of normal human nails.
• Melatonin treatment in peri- and postmenopausal women elevates serum high-density lipoprotein cholesterol levels without influencing total cholesterol levels.
• Metabolism in deoxyribonucleotides. IV. Purification and properties of deoxycytidine kinase of calf thymus.
• Nonadiabatic couplings from time-dependent density functional theory. II. Successes and challenges of the pseudopotential approximation.
• OC118: Sequential laser coagulation of placental communicating vessels for twin-twin transfusion syndrome: a new approach to prevent fetal demise of a donor.
• Overproduction and purification of the Tn3 transposase.
• Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate.
• P36.03: Successful treatment for reversal of twin-twin transfusion syndrome by fetoscopic laser photocoagulation of placental communicating vessels.
• Polymethylmethacrylate capillary kidney highly permeable to middle molecules.
• Potential link between estrogen receptor-{alpha} gene hypomethylation and uterine fibroid formation.
• Primary amenorrhea in an 18-year-old Japanese female with sensorineural hearing loss and anosmia: a new sydrome?
• Relationship between decreased expression of squamous cell carcinoma antigen 2 and E-cadherin in primary cervical cancer lesions and lymph node metastasis.
• [Check points in nursing management. Advice on activation of stereotyped nursing teams]
• [Leadership in nursing and activation of nurses]
• [Unexpected treatable dyspnea caused by intratracheal granuloma in an amyotrophic lateral sclerosis patient with mechanical ventilation]